Sunday, 28 January 2018

AMH is an important marker for female fertility potential. If AMH (A hormone secreted by ovaries) is too low then she is medically called is DOR or POF.

Where is the source of AMH? We want to learn more about AMH. Anti-Müllerian Hormone (AMH) has long been known to provide insight into ovarian function. It is produced by small, growing follicles, thus providing us with quantitative information on ovarian reserve ,The study findings support the hypothesis that AMH levels are biomarker of oocyte and embryo reproductive health besides predicting number of oocyte obtained by COH (Capability of Ovaries to produce eggs by whipping the ovaries by strong high dose hormones called gonadotophins mainly FSH).


In the 21st century most of us have heard the name of Donor Egg e.g. third party reproduction (by using egg of some other women) is also called egg sharing. This is a variety of artificial reproduction (ART procedure). The egg of other women is only considered when a particular women is unable to produce her own egg due absence of her total no. of eggs which God gave her at the time of birth. The cause of early and speedy loss of all eggs by the age of 35 yrs or say 40 yrs is not known to us with certainty.
When to then consider donor egg if she (POF case) is desirous of a baby to be carried and nourished in her own womb? It’s true that not all women will be considered for donor egg. Some criteria have been framed by different recognized International fertility societies. I’m mentioning one of such criteria where we doctors should seriously counsel about donor egg-to be fertilized with the husband’s sperm and then the young baby so formed inside the test tube is to be transferred (ET-Egg transfer by a special tube) in the recipient (Womb) either in the same cycle or else this newly formed baby (Embryo) may be preserved in the cryocan to be thawed and then put to womb of the desired candidate in a subsequent month after preparing the bed (Endometrium) inside the womb so that the young embryo can get good nutrition once transferred to the prepared womb which is relatively thin and has become small due to stoppage of own female hormones. This entire process is called endometrial preparation- by giving her good amount of estrogens from outside which she can’t produce of her own.

Then when we the doctors should allow a women for receiving a donor egg? Of the four criteria/parameters mentioned below at least two of the following criteria should be present.

1) AMH between O.5 and 1
2) Antral follicle count (follicle between 2-5 mm) less than 4 AF
3) Maternal age more than 40 years.

 4) FSH 3rd day more than 20 IU. &  5) THOSE WOMENPoor responders fit for egg donation.


  Then to summaries the whole issue of counseling about donor egg: What are the criteria of DOR & Egg Donation Programme?

Two of the following criteria must be positive to qualify to receive donor egg.
AMH between .5 and 1
Antral follicle count (follicle between 2-5 mm) less than 4 AF
Maternal age more than 40
FSH 3rd day more than 20 IU
 Poor responders fit for egg donation
Nomo-responders --- FSH 15 -20
Antral Follicle count 5-7
AMH 2-4 (above 5.8 AMH in PCOS)

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