Where is the source of AMH? We want to learn more about AMH. Anti-Müllerian Hormone (AMH) has long been known to provide insight into ovarian function. It is produced by small, growing follicles, thus providing us with quantitative information on ovarian reserve ,The study findings support the hypothesis that AMH levels are biomarker of oocyte and embryo reproductive health besides predicting number of oocyte obtained by COH (Capability of Ovaries to produce eggs by whipping the ovaries by strong high dose hormones called gonadotophins mainly FSH).
In the 21st
century most of us have heard the name of Donor Egg e.g. third party
reproduction (by using egg of some other women) is also called egg sharing.
This is a variety of artificial reproduction (ART procedure). The egg of other
women is only considered when a particular women is unable to produce her own
egg due absence of her total no. of eggs which God gave her at the time of
birth. The cause of early and speedy loss of all eggs by the age of 35 yrs or
say 40 yrs is not known to us with certainty.
When to then
consider donor egg if she (POF case) is desirous of a baby to be carried and
nourished in her own womb? It’s true that not all women will be considered for
donor egg. Some criteria have been framed by different recognized International
fertility societies. I’m mentioning one of such criteria where we doctors
should seriously counsel about donor egg-to be fertilized with the husband’s
sperm and then the young baby so formed inside the test tube is to be transferred
(ET-Egg transfer by a special tube) in the recipient (Womb) either in the same
cycle or else this newly formed baby (Embryo) may be preserved in the cryocan
to be thawed and then put to womb of the desired candidate in a subsequent
month after preparing the bed (Endometrium) inside the womb so that the young
embryo can get good nutrition once transferred to the prepared womb which is
relatively thin and has become small due to stoppage of own female hormones. This
entire process is called endometrial preparation- by giving her good amount of
estrogens from outside which she can’t produce of her own.
Then when we
the doctors should allow a women for receiving a donor egg? Of the four
criteria/parameters mentioned below at least two of the following criteria should
be present.
1) AMH between O.5 and 1
2) Antral follicle count (follicle between 2-5 mm) less than 4
AF
3) Maternal age more than 40 years.
4) FSH 3rd day more than
20 IU. & 5) THOSE WOMENPoor
responders fit for egg donation.
Then to summaries the whole issue
of counseling about donor egg: What are the criteria of DOR & Egg Donation
Programme?
Two of the following criteria must be positive to qualify to receive donor egg.
AMH
between .5 and 1
Antral
follicle count (follicle between 2-5 mm) less than 4 AF
Maternal
age more than 40
FSH 3rd
day more than 20 IU
Poor responders fit for egg donation
Nomo-responders
--- FSH 15 -20
Antral
Follicle count 5-7
AMH 2-4 (above 5.8 AMH in PCOS)
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