Sunday, 28 January 2018

We all know about AMH in females. How many members are aware of AMH in males? Please try answering. Thanks.


The Sertoli cells secrete a glycoprotein known as anti miillerian hormone (AMH), which causes regression of the paramesonephric duct system in the male embryo and is the likely signal for differentiation of Leydig cells from the surrounding mesenchyme . The Leydig cells produce testosterone nd with the converting enzyme 5a –reductase, dihydrotestosterone. Testosterone is responsible for evolution of the mesonephric duct system into the vas deferens, epididymis, ejaculatory ducts and seminal vesicle. At puberty testosterone leads to spermatogenesis and changes in primary and secondary sex characteristics. Dihydrotestosterone triggers the development of the male external genitalia and the prostate and bullbourethral glands. In the absence of testis determining factor the medulla regresses and the cortical sex cords break up into isolated cell clusters (the primordial follicles ).

The germ cells differentiate into oogonia and enter the first meiotic division as primary oocytes at which point development is arrested until puberty . In the absence of AMH the mesonephric duct system degenerates although in at least one fourth of adult women, remnants may be found in the mesovarium or along the lateral wall of the uterus or vagina .

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