Monday, 17 June 2019

Vaginal progesterone in Preterm labour


) 200 mg micro when ?? When  to prescribe 200 mg Micronized Progesterone soft gel/ or Crinone gel ( 90 mg) at morning ?  In cases of singleton pregnancy, with or without past history of PTBà but there is  recent sonological  evidence of a) short cervical length < 25 mm at 18-23 weeks.  The said study group have observed that is used vaginally (not oral) and not 100mg vaginal micronized progesterone. FIGO too have strongly recommended this preventive steps and FIGO Group suggested no oral Tab but either 200mg Micronized Progesterone (at nighttime)  / Crinone or Susten gel , 90 mg (  Cost per gel ₹112 -)/
₹93.26/gm of Vaginal gel

All such gel formulations should be applied at morning-  for reason not clear to me    .  Anyone can  push the soft gel at night  time but as hands becomes unclean for the whole night  I, Dr Pal feel, in this context that      husband if present at home may push the tab at nighttime  so that she need not  stand up soon after the micro 200mg is inserted at bed time by herself, Counsel: that not to  use tampons or other vaginal products for at least 6 hours before and 6 hours after using Crinone 8% Vaginal gel. So to summarize all short Cx of 25 mm at 18-23 weeks of gestation. No oral , No Inj 17 OH progesterone ( Source:-Extract  from a Book: titled” Progesterones in Obstetrics & Gynaecology”: Sponger Publications: Ed Howard JA,carp :: ISBN 978-81-322-4499-8: Ed 2015  p.89  
2.Naturogest 8% Vaginal gel(Zydus Cadila₹93.26/gm of Vaginal gel
3. Gestone 8% Vaginal gel(Ferring Pharmaceuticals:₹7.35/gm of Vaginal gel)%
4)Urea Vaginal gel(Intas Pharmaceuticals Ltd) ₹126.92/gm of Vaginal gel
5) Emprogest 8% Vaginal gel (Emcure Pharmaceuticals Ltd₹199.25/gm of Vaginal gel)


What are the other uses of 200 mg of micronized Progesterone;-In women who had one episode of Thr. Preterm labour in current pregnancy?  
 400 mg when?? Four hundred Progesterone is used  in cases of Acute tocolysis that too for 48 hrs only later after cessation of contractions one should taper the dose to  200mg Prog vaginally daily till 36weeks., Therefore in  established PTL where we intend to use  acute tocolysis then vaginal micronized 400 mg  daily in divided doses in conjunction with other parenteral or tocolytics (like Nifedipine,  Ritodrine, )


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