No. 5 type : The fifth type of known genetic disorders
(also called syndromes) is CBAVD. A syndrome with which infertility specialists are well aware of.What is CBAVD? This is again another kind of Genetic
Disease of males: Such syndrome is observed in about 1% of all infertile males
and in about 6% of men with Obst azoospermia. Any of two genetic abnormalities
can yield to such Vasal aplasia 1) mutations of CFTR gene (most common etiology)
or 2) Mutations of genes responsible for mesonephric ductal differentiation
from which vas develop. Clinical examination revel partial or complete absence
of Vas deferens or of the cauda or aplasia localized to Corpus of the
epididymis only. It is not uncommon to
have some pancreatic and or lungs diseases – depending on the degree of gene
involvement. (See Book on male Infertility-p. 155. - Eds. Larry I Lipshultz et
al & A Treatise on Male Infertility-A to Z –A concise encyclopedia Ed. JMG Hollanders, Publishers: - The Parthenon
Publishing Group-Yr 1996) P- 29 & p. 76.
May also see Book on “Male Infertility” - Eds Larry I
Lipshultz et al, -p. 155. & Book on Male Reproductive Dysfunction, Ed S C
Basu, 2nd Ed, Jaypee Bros .p.178,
Contd….(when to insist on evaluation of special
microscopy of ciliary movements of sperm tails & flagellar whips?)
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