Genetic disease of male which can cause severe astheno-zoospermia/ Azoospermia? There are about 5 such genetic syndromes which can lead to severe motility disorders or even azoospermia.

Genetic Disease of Males with seminal disorders :- Think of primary ciliary dyskinesis. Then what is primary ciliary dyskinesis? If a man suffers from Chr. Upper RTI along with severe sperm motility disorder then the person is termed as a case of “Immotile Cilia Syndrome”. Ciliary Dyskinesis have three major types as per observations by electron microscopy. These subtypes are a) only dynein arm defects b) only defective radial spokes and c) defective microtubular dispositions. But by far the common defect is caused by dynein arm defects.

However,   axonemal microtubules in ciliary and flagellar regions are uncommonly seen. (Source: TB- of MALE INFERTILITY: Eds Larry I Lipshultz et al).

p. 155. 2) Then, what is Kartagener’s syndrome (KS).  This syndrome was first described by Kartagener’s in 1933. Association of primary ciliary dyskinesia along with situs inversus is termed as Kartagener’s syndrome (KS).(to be contd.)