How to assess of Male Infertility:-Ans:
Male factor
infertility is the only cause of infertility in approximately 30% of couples
and a contributing factor in another 20% to 30%. Assessment of the
infertile couple includes evaluation of the male partner by history,
examination, and semen analysis.
What tests for male subfertility? Important elements of the history include
prior paternity, a history of cryptorchidism, medical and surgical history,
sexual dysfunction, and any use of medications, tobacco, alcohol, or illicit
drugs. On the physical examination, testicular abnormalities such as a
varicocele or absence of the vas deferens can be detected. If the semen
analysis is abnormal, it should be repeated after at least 1 month by a
laboratory that adheres to World Health Organization.
Limitations of RSA: Although
semen analysis is routinely used to evaluate the
male partner in infertile couples, the discriminatory ranges are not clearly
defined.
A study by Guzick and colleagues concluded “threshold values for sperm
concentration, motility, and morphology can be used to classify men as subfertile, of indeterminate
fertility, or fertile. None of the measures, however, are diagnostic of
infertility.” The reference values for fertile, indeterminate, and
subfertile ranges for semen analysis parameters as identified by regression
analysis is mentioned below.. Despite its limitations, semen analysis remains
the most important tool in the investigation of male factor infertility. If any
abnormalities are repeatedly detected on a semen analysis, referral to a
urologist may be warranted. The treatment of severe male factor infertility
including azoospermia has been revolutionized with the combination of in vitro
fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Health Organization
Criteria for a Normal Semen Analysis(old standars)
Classifying
the semen report as -àFertile, Indeterminate, and Subfertile
Ranges as identified by Regression Analysis World Health Organization Criteria for a
Normal Semen Analysis: Old standards “ Currently there have been many changes
Criteria
|
Parameters
|
Volume
|
2.0–5.0 mL
|
pH
|
7.2–7.8
|
Sperm concentration
|
≥ 20 × 106/mL
|
Total sperm count
|
≥ 40 × 106 spermatozoa
|
Motility
|
≥ 50% with forward progression or ≥ 25%
with rapid
|
linear progression within 60 min after
collection
|
|
Morphology
|
≥ 50% with normal morphology
|
Viability
|
≥ 75% live (ie, excluding dye)
|
White blood cells
|
≤ 1 × 106/mL
|
Fructose (total)
|
≥ 13 mol/ejaculate
|
Adapted from Ann Ist Super Sanita.
2001;37:I–XII, 1–123 By such report the clinicians classifies semen report as
Previously, the postcoital test (PCT) assessing the sperm motility
in a sample of postcoital cervical mucus was considered an integral part of the
basic infertility evaluation. However, past investigations revealed a poor
correlation between postcoital sperm motility and pregnancy outcome.In
addition, a 1995 blinded, prospective study demonstrated poor reproducibility
of the test among trained observers, further questioning the validity of the
PCT as a diagnostic tool. Today, the PCT has been largely abandoned and we do
not recommend it as a component of the standard infertility investigation
No comments:
Post a Comment