Sunday, 22 March 2020

Insulin sensitizers-DCI


(not all men / women having insulin resistance)  use inositol phosphoglycan mediators , AS such  if there is  a deficiency of the d-chiro-inositol phosphoglycan mediator then the action of insulin may result in resistance to insulin in a subset of PCOS women, but not all cases.
Some men & women  may involve low-molecular-weight inositol phosphoglycan mediators as a second pathway for entry of glucose in cells . When insulin binds to such kind of uncommon  receptor, mediators of this class(Myo inositol /DCI driven  pathway of cell)  are generated by hydrolysis of glycosyl-phosphatidyl-inositol lipids located at the outer leaflet of the cell membrane. Released mediators are then internalized and affect intracellular metabolic processes. Although different species (about seven types if I remember correctly) have been identified, an inositol phosphoglycan molecule containing d-chiro-inositol and galactosamine is known to have a role in activating key enzymes that control the oxidative and non-oxidative metabolism of glucose. Therefore a  deficiency of the d-chiro-inositol phosphoglycan mediator of the action of insulin may result in resistance to insulin. Insulin resistance has been linked to decreased urinary excretion of chiro-inositol (a component of the putative d-chiro-inositol phosphoglycan mediator) in humans with impaired glucose tolerance. 

Few decades back , in animal studies it has been shown that administration of d-chiro-inositol decreased hyperglycemia in rats with diabetes and improved glucose tolerance in normal rats, such was also the results monkeys with varying degrees of insulin resistance, d-chiro-inositol accelerated the disposal of glucose and decreased insulin secretion. Therefore it is logical to believe
That d-chiro-inositol, by virtue of its ability to increase sensitivity to insulin, would have beneficial effects on ovulation and ovarian production of androgens in women with the polycystic ovary syndrome.


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