PCO and ill effects on blood vessels?? Genesis of hypertension and MI & stroke at an enhanced rate in women with PCO

 Nowadays  it is clear that PCOS  is a pro inflammatory state    and  emerging   data suggest that chronic low grade   inflammation   supports  the development of  metabolic aberration and ovarian dysfunction .CRP is the most    reliable    circulating marker of chronic low grade   inflammation in PCOS  . Recently    CRP   was found to be a direct promoter of the   atherosclerotic   processes and  endothelial cell  inflammation   leading to  athero thrombosis . CRP has a  direct   role in the vascular  inflammatory   process  stimulating  the release   of inflammatory   cytokines  and increasing   endothelial  expression of cellular  adhesion   molecule  which mediate    leukocyte  migration . Findings of a study  suggest that increased  cardiovascular   risk may be seen in 83.3 % of the PCO women with CRP >  2.42  mg /1 .CRP  values < 1  mg / 1 are  considered low  risk  1-3   mg/ 1 are considered  intermediate  risk and  3-10   mg / 1    are considered high   risk for cardiovascular   disease .  Why PCO is compared with Viper venom?? Nowadays  it is clear that PCOS  is a pro inflammatory state    and  emerging   data suggest that chronic low grade   inflammation   supports  the development of  metabolic aberration and ovarian dysfunction .CRP is the most    reliable    circulating marker of chronic low grade   inflammation in PCOS  . Recently    CRP   was found to be a direct promoter of the   atherosclerotic   processes and  endothelial cell  inflammation   leading to  athero thrombosis . CRP has a  direct   role in the vascular  inflammatory   process  stimulating  the release   of inflammatory   cytokines  and increasing   endothelial  expression of cellular  adhesion   molecule  which mediate    leukocyte  migration . Findings of a study  suggest that increased  cardiovascular   risk may be seen in 83.3 % of the PCO women with CRP >  2.42  mg /1 .CRP  values < 1  mg / 1 are  considered low  risk  1-3   mg/ 1 are considered  intermediate  risk and  3-10   mg / 1    are considered high   risk for cardiovascular   disease .