PCOs and genes

Not one particular shoe will fit all women!!!!! Any woman with PCO are usually are treated with variety of drugs . Unfortunately in fair no of cases such primary agent don’t work. Can we select the most appropriate agent after UNLOCKING the defective genes and then select the right drug for right women; Which are the culprit genes in development of PCO in embryonic life ??

The first genetic mutation for PCO genesis: LH gene mutation is the most common (major ) cause of genetic diseases of PCO and that mutation occurs in either in gametogensis(male / female) or post immediate fertilization growth disorders : To remind all of you that LH hypersecretion is present in almost 50 % of PCOS women, and two mutations, Trp8Arg and IleI5Thr, could be the cause of an abnormal LH p molecule LH : LH hypersecretion is present in almost 50 % of PCOS women, and two mutations, Trp8Arg and IleI5Thr, could be the cause of an abnormal LH p molecule The first PCOS GWAS (genome-wide association studies) identified LH/choriogonadotropin receptor (LHCGR) as a susceptibility gene for PCOS: the interaction of LHCGR and its ligand, LH, plays a fundamental role in the folliculogenesis of mammals.

Can HHcyst itself de novo initiate PCO if the female foetus is in uero an=d mother is having high Homocysteine? Daig & remedy to avert HHcys in pregnancy period ?? How relevant to maintain H.Hcy ( avoiding excess homocyeine) in normal levels while planning pregancy or in pregancy period?? Can HHcyst itself de novo initiate PCO?? A study suggested that LHCGR might participate in the physiopathology of PCOS by deviations in the methylation statuses of its promoter CpG sites, a hypomethylation in particular.