Does IUI procedure really helps in cases of isolated defect of morphological disordes of sperms??

 

Does IUI procedure really helps in cases of isolated defect of morphological disordes of sperms??;;

Abstracts of the 26th Annual Meeting of ESHRE, Rome, Italy, 27 June – 30 June, 2010

How helpful is IUI procedure  in morphological abnormalities of sperms-A study : Poster presenation from :  the 26th Annual Meeting of ESHRE, Rome, Italy, 27 June – 30 June, 2010

Reproductive outcomes using Kruger’s strict criteria in IUI

Cycles  >    Conclusions: How helpful is IUI procedure  in cases  Teratozoospermia as a lone defect ?? 

Sperm morphology is a widely used parameter to consider IUI.

Our results indicated that, at least in our facilities, it does not predict IUI outcomes

in terms of PR and MR. The narrow range of sperm morphology classification

may be responsible of these results, although WHO criteria to classify

morphology seems to show similar results. In the view of these results, there

is no clinical usefulness of morphological classification at least to predict PR

and MR.

 

 

F.Q. Quintana1, Z.L. Zaloa Larreategui2, I.P. Iratxe Peñalba1, S.O. Sara Ortega1,

M.M. Monica Martin1, G.Q. Guillermo Quea3, J.S. Jose Serna3

 

1IVI Bilbao, Andrology laboratory, Bilbao, Spain

 

2IVI Bilbao, IVF laboratory, Bilbao, Spain

 

3IVI Zaragoza, Gynecologist, Bilbao, Spain

 

Introduction: It is well known that Intrauterine Insemination (IUI) cycles combined

with ovarian stimulation along with induction of ovulation has become

the first line of treatment for infertility. The aim of this study was to determine

the effect of morphology as a seminal parameter in order to evaluate reproductive

success in patients undergoing IUI in our facilities.

 

Material and Methods: Retrospective study including 438 couples with unexplained

infertility, undergoing IUI cycles. The period of the study ranges from

December 2005 to September 2009.

All patients were stimulated with rFSH

(Puregon; Organon) starting cycle day 3, once ovarian quiescence was confirmed

by transvaginal ultrasound scan, and estradiol and progesterone blood

tests when needed. Starting dose ranged between 75 and 150 IU, depending on

patients’ age and BMI. Final maturation was triggered with 250 mg of rhCG

when at least one follicle reached 17 mm in mean diameter. Two IUI were

scheduled at 16 and 28 hours since rhCG injection. Sperm samples were collected

into a sterile container 2 h prior insemination, by masturbation after a

minimum of two days of abstinence. Kruger´s strict criteria were applied to

evaluate sperm morphology. According to percentage of normal forms, samples

were classified into Group A (1-6% normal sperms) and Group B (7-14%).

Pregnancy Rate (PR) and Miscarriage Rate (MR) were compared in both

groups. t-test was applied.

 

Results: Although there is a trend towards better outcomes with increasing

number of normal sperm, there were no statistically significant differences between

both groups in terms of PR [A: 21.03% (82/390); B: 29.17% (14/48)] and

MR [A: 2.31% (9/390); B: 2.08%, (1/48)].