Googly:-
Not all hairs in a young women are due
to androgens
High serum level of androgens neither the excess
hairs are due to more androgens receptors. answer
by 20 second and win a cash prize of Rs. 0.05/- by the year 2060 positively. Which area of body responds to only high dose
of androgens and mandate thorough investigation??
-Hairs in the following this area cannot be
considered as due to PCOS or physiological. Tumours of adrenal /Ovary remain a
great possibility. Follicles in the distribution associated with male patterns of facial
and body hair (midline, facial, inframammary) require higher levels of
androgens, as seen with normal testicular function or abnormal ovarian or
adrenal androgen production.
Androgen effects on hair vary in relation to
specific regions of the body surface. Hair that shows no androgen dependence includes
lanugo, eyebrows, and eyelashes.
A).The hair of the limbs and portions of the trunk
exhibits minimal sensitivity to androgens.
B)AXilla and pubic region Pilosebaceous units of the axilla and pubic region are sensitive to low
levels of androgens, such that the modest androgenic effects of adult levels of
androgens of adrenal origin are sufficient for substantial expression of
terminal hair in these areas.
C). Scalp hair
is inhibited by gonadal androgens, in varying degrees, as determined by age and
genetic determination of follicular responsiveness, resulting in the common
frontal-parietal balding seen in some males and in virilized females. Hirsutism results from both increased
androgen production and skin sensitivity to androgens.
Skin sensitivity depends on the genetically
determined local activity of 5a-reductase, the enzyme that converts testosterone to
dihydrotestosterone (DHT) the bioactive androgen in hair follicles.
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