In conclusion, although estradiol is best recognized as sex
hormone that regulates the development and function of reproductive hormone
across the entire mammalian species, ever-growing evidence demonstrates its
multi-faceted nature in exerting its role in non-reproductive organs and
systems under normal as well as pathological conditions. It will be exciting to
see what other functions estradiol may play in local tissues and from where the
hormone is supplied to those sites.
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