Role of Magnesium therapy in PCO
Many women with PCOS have
significantly low serum and total magnesium, contributing to the progression of
insulin resistance to type 2 diabetes and heart disease (Kauffman 2011).
Magnesium insufficiency is
common in poorly controlled type 2 diabetes patients. In one study, 128
patients with poorly controlled type 2 diabetes received a placebo or a supplement
with either 500 mg or 1000 mg of magnesium oxide (300 mg or 600mg element
magnesium) for 30 days. All patients were treated also with diet or diet plus
oral medication to control blood glucose levels. Magnesium levels increased in
the group receiving 1,000 mg magnesium oxide daily but did not significantly
change in the placebo group or the group receiving 500 mg of magnesium. The
author suggested prolonged use of magnesium in doses that are higher than usual
is needed in patients with type 2 diabetes to improve control or prevent
chronic complications (De Lourdes Lima 1998).
In a related study, 63
diabetics with below normal serum magnesium levels received either 2.5 grams of
oral magnesium chloride daily or a placebo. At the end of the 16-week study
period, those who received the supplement had higher blood levels of magnesium
and improved control of diabetes, as suggested by lower hemoglobin A1c (HbA1c)
levels (Rodriguez-Moran 2003).
Another study found that oral
magnesium supplements helped insulin resistant individuals avoid developing
type 2 diabetes (Mooren 2011).
Since magnesium improves
insulin-mediated glucose uptake and insulin secretion in type 2 diabetes
patients, it is considered a critical mineral for women with PCOS.
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