Saturday, 24 August 2019

How to score the Malign potential of a mole??


How to follow up  a case of mole-Risk scoring about recurrence:
Because earlier it was believed (even now some oncologists   are convinced) that at the time of primary evacuation there are some salient features which may foretell the possibility of developing Neoplasia later. Therefore more frequent follow up is warranted in such high risk cases. That is classifying moles at first admission-as “low risk moles” or “higher risk category moles”. The association of following six points was considered as high risk group with increased possibility of Chorio-Ca in later life. Such adverse points are 1) too much uterine enlargement 2) initial beta hCG titre is high 3) association of Theca Leutien Cysts   4) Rasp Distress Syndrome as happened in this case 5) H P evidence of too much proliferation .But this risk scoring is now fading out and this risk categorization is not to be confused with WHO Prognostic Scoring for GTN-which is done AFTER the onset frank Ca/ GTN for choosing mono/ multiple chemotherapeutic agents. So my dear forum members Pl document all these and preferably keep one copy in office file/ N Home records.
Comprehensive Diagnostic work up-& formulate  therapeutic modality -which   is essential prior to initiation of Chemo:-6) Prognostic scoring frames by WHO is not be confused with previous scoring which foretells the possibility of developing Chorio Ca in later life, thereby mandate frequent follow up than “minimal risk) in first time evacuation .According to WHO points to be considered are age, Antecedent preg, Interval period between primary mole and later reappearance of symptoms (? Chorio Ca), blood group, site & No of metastasis, prior chemo and surprisingly blood group. Post- evacuation contd haemorrhage for couple of weeks... WHO scoring is a modification of Bags awe scoring? Charring Cross Classification of established GTN is also another modality of scoring and selecting appropriate Chemo. Overall risk of turning ordinary moles (I mean complete moles) which we come across varies from 10-30% but there are series where only 1 in 40 moles turns out to be Ca in later life racial differences are great, not to speak of Singapore, China, Japan.





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