Research shows a clear link between chromium
and glucose metabolism. Indeed, chromium is one of the most widely studied
nutritional interventions in the treatment of glucose and insulin-related
irregularities. Chromium picolinate specifically is the form that has been used
in a number of studies on insulin resistance. Researchers at the University of
Texas Health Science Center at San Antonio found that chromium picolinate (200
mcg/day) improves glucose tolerance when compared with a placebo (Lucidi 2005)
in women with PCOS.
Lipoic Acid How useful in controlling PCO?? Is there any role of Lipoic Acid to reduce the vascular
endothelial dysfunction in PCO
Overwhelming evidence suggests that lipoic
acid may be critical not only for maintaining optimal blood sugar levels (by
helping the body use glucose), but also for supporting insulin sensitivity and
key aspects of cardiovascular health, such as endothelial function. A review of
experimental studies reveals that lipoic acid helps relieve several components
of metabolic syndrome—a constellation of risk factors that often precedes
full-blown type 2 diabetes. It appears that lipoic acid reduces blood pressure
and insulin resistance, improves lipid profile, and reduces weight. Based on
the results of key clinical studies, scientists are sanguine about lipoic
acid’s potential as a therapeutic agent for individuals with metabolic syndrome
(Pershadsingh 2007). Similarly positive effects have been observed in women
with PCOS. In a 16-week study, women with PCOS were given 600 mg of lipoic acid
twice daily, and, over the course of the study period, exhibited a sharp
improvement in insulin sensitivity, and a reduction in triglycerides. Lipoic
acid therapy also is associated with an improved LDL-particle pattern (or “bad”
cholesterol particles), indicating a reduction in cardiovascular risk
(Masharani 2010).
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