Genes & pregancy losses

RPL : Q What % of conception proceed to  live birch?? Ans: Human reproduction is remarkably inefficient; nearly 70% of human conceptions do not survive to live birth.

What is the commonest cause of spont abortion?? Ans;- the most common cause for spontaneous loss, is  fetal aneuploidy is particularly in the first trimester of pregnancy. Although losses may be due to A) owing to de novo fetal aneuploidy occur at similar frequencies among women with sporadic and recurrent losses, B) Equal no have  couples additional associated genetic factors and C) The other causes of RSL /RPL are  monogenetic etiologies.

Q, How useful is Genetic testing of the products of conception from couples experiencing two or more losses?? Ans:-Genetic testing of the products of conception from couples experiencing two or more losses may aid in defining the underlying etiology and in counseling patients about prognosis in a subsequent pregnancy.

How important is Parental karyotyping of couples  Ans:-Parental karyotyping of couples who have experienced recurrent pregnancy loss (RPL) will detect some couples with an increased likelihood of recurrent fetal aneuploidy; this may direct interventions.

How important is PGS?? The utility of Perimplantation genetic analysis in couples with RPL is unproven, but new approaches to this testing show great promise.