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To what extent we should investigate
prior to initiation of first cycle of CC ?: :The
philosophy or say logic in the
minds of treating physicians are as most of the women responds to 2-3 cycles of
CC at the dose of 100 mg of CC , so
doctors becomes very hopeful and avoids detailed investigations , By contrast in cases of IUI , not to speak of ART investigations are detailed. .-As large
no of women ovulate with CC at the dosage of 50-100-150 mg of CC , most of us don’t
estimate or evaluate thoroughly before initiating initial few spells of CC. This is more true if she is of average
BMI and with no clinical evidence of hyperinsulinaemia, hyperandrogenaemia, galactorrhoea
and her cycles are regular(eumenorrhoic) though most PCO women has H/O Oligomenorrhoea(delayed
periods.
·
Most of us hesitate to investigate thoroughly prior to
initiate CC, more so when age of female partner is less than 25 yrs of age .Because most of
clinicians take it granted that if woman’s
androgen profile, glycemic profile, & PRL are normal as she is eumenorrhoic
and many report pertaining to subtle changes of those hormones that is capable
of adversely affecting oogenesis may not
be picked up by currently available biochemical
assays like androgen profile , insulin assays
& glycemic profiles.
·
Such minor changes are often difficult to pick by ordinary tests.
How many members agree with this philosophy of minimal testing if female partner
is aged 25 yrs and trying time is 2 yrs only. How many of us will insists on
AMH, Day 3 AFC, Progesterone on day 3(basal) & on day 9 of cycle (premature
Luteinization) , DHEASO4, HBA1C ?? Do members believe such expenses are worth
doing and also consider that asking for too many tests will add to the existing stress on the couple . What
is your practice pattern.Pl share your views on this very important issue. How
many of you believe this omission is a bad clinical practice?? .
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