Benefits of
Zn in the system?? Through its effects on cortical plasticity zinc controls the
functions of the hippocampus which affects learning and memory Its deficiency
can alter behavior mental function increase susceptibility to epileptic
convulsions and may be associated with depression Beurosynaptic transmission is
controlled by zinc which when impaired
leads to ischemic neuronal injury and
neurodegeneration Zinc metabolism is also altered in Alzheimer’s disease and
other neurodegenerative diseases.
Other ill
effects of zinc deficiency :-
Cancer :
Levels of zinc in serum and malignant tissues in cancer are abnormal The
antioxidant action of zinc ameliorates
oxidative stress. Zinc deficiency causes pro inflammatory conditions which
increases the risk of reactions of biomolecules with environment carcinogens
resulting in DNA damages increasing the risk of mutation and malignant
transformation .
Aging: With
advancing age zinc deficiency results in a decline in immunity neuroendocrine function and increased
apoptosis leading to a chronic stress like condition . This leads to increased
infection relapses in the elderly and an increased risk of
cardiovascular disease.
Sensory
system
Loss of
taste acuity is a clinical sign of zinc deficiency it can also affect ocular auditory and
olfactory systems particularly through its central role in neuronal signal
transmission.
Benefits of
Zinc Supplementation
Benefit
of Zinc:-1) In infants
Zinc
supplementation improves neurodevelopment
growth and prevents infection in infants Preventive zinc supplementation
for 2 weeks in infants provided a 39% reduction of diarrhea morbidity and
provided protection for 5 months. In neonates with sepsis zinc supplementation
reduces mortality and promotes mental development.
Benefit
of Zinc:-2 In children :- Pneumonia accounts for 15% of all childhood deaths
under 5 years which is increased to 19% in developing countries The world
Health organization estimates that zinc deficiency accounts for 13% of lower
respiratory tract infections. A review
and meta analysis included 6 randomized controlled trials on the use of
zinc supplementation in the prevention of pneumonia in children aged 2 months
to 59 months and the data was analyzed using a fixed effects model.
Zinc supplementation reduced the incidence of pneumonia by 13%
,Zinc statistically significantly reduced the prevalence of pneumonia by 41% .Subgroup
analysis revealed that zinc reduced the incidence of pneumonia defined by specific clinical
criteria by 21% but had no effect on
lower specificity pneumonia case
definition
Zinc
supplementation has shown beneficial effects
in childhood infectious diseases
particularly diarrhea pneumonia as well as improving growth. Zinc supplementation
resulted in a 20% reduction of
diarrhea incidence shortened th duration of illness and prevented recurrences
All cause diarrhea and pneumonia hospitalizations were reduced by 59,31 and 71%
respectively in children treated with zinc supplementation Diarrhea
specific mortality was reduced by 13% and pneumonia provided
zinc supplementation a significant improvement in height was observed
Benefit of Zinc:-No 3:-Suboptimum Zn, low immune status :--In adults immune function Zinc
supplementation prevents respiratory disease such as common colds. It modulates
cytokine profiles preventing pro inflammatory conditions and has antioxidant
action
Benefit
of Zinc:-No 4:-Zn Deficincy & ill effects on Skin and wounds :Zinc promotes tissue growth and
prevents tissue damage by encouraging
wound healing . Its anti inflammatory effects improve skin conditions such as
acne and cold sores. It is also beneficial in alopecia. Benefit of Zinc:-No
5 :: Neurological effects : It
boosts mental health improves mood and prevents depression .Sensory effects
: Zinc improves age related macular degeneration and night blindness improves
olfactory senses and taste acuity
Benefit
of Zinc:-No 6:--
Zn suppl: prevention of cancer -Cancer : The antioxidant effects of zinc prevent tissue
damage and generally prevent malignancy particularly in cases of prostate
cancer. bone loss : Zinc is a component of hydroxyapatite which strengthen
bones. Appetite : Zinc supplementation improves appetite prevents anorexia and reduces fatigue. In women Zinc
supplementation can improve premenstrual syndrome reduce post menopausal
complications Improve fertility and birth outcomes. It improves lactation
which is important for the well being of both the mother and
infant.
Benefit
of Zinc:-No 8:- Counter attacks of infection
in infants:--Zinc reduced risk of treatment failure
in infants with serious bacterial infection. Over 25% of the one million infant deaths that occur
annually in India are due to serious bacterial infection Bhatnagar et al
conducted a multicenter randomized double blind placebo controlled trial to
estimate the efficacy of zinc as an
adjunct to antibiotics in reducing the risk of treatments failure in infants
aged between 7and 120 days with a
probable serious bacterial infection
patients were administered zinc + antibiotics or only antibiotics till recovery
or for a maximum of 21 days .
Benefit
of Zinc:-No 9 :-Prevention of Chr diarrhoea in infants & children:- Preventing pneumonia in young
children with zinc The efficacy of zinc was higher in infants with
diarrhea at enrolment compared to those without .Treatment efficacy and case fatality were
not significantly different between underweight infants and those not
underweight.The mean change in serum
zinc concentration from enrolment to recovery
was higher in the infants given zinc compared to placebo
Benefits of Zn suppl:-No 10:-Zinc improves bone density
Thalassemia
is associated with low levels of serum zinc and 60% of thal patients have low bone
mass as a result of the same. A randomized multicenter placebo controlled study
was conducted to determine the effect of zinc or placebo on bone density in
young patients with thal and a low bone
mass patients were treated and evaluated over 18 months . BMD improved as plasma zinc level
increased by 14.7% and 15.2% respectively at 3 and 6 months in
the zinc group but not in the placebo group .At the end of the study the zinc
group had significant increases in whole
body bone mineral content and areal BMD
compared to placebo
Adjusted
spine and hip a BMD z scores both decreased by 0.3 standard
deviation
Lateral
spine BMC and a BMD increased by a mean of 10.9% and 3.8% respectively compared
to a 1.3% increase and 2.1% decrease in the placebo respectively
Whole body BMC and a BMD increased by 5.7% and 2.9% in the zinc
group respectively and these increased by 1.4% and
decreased by 1% in the placebo group respectively . Zinc supplementation was
well tolerated with good adherence. Zinc supplementation improves glucose
parameters .The relationship of zinc and insulin has been well established and
can provide a protective effect in type 1 and type 2 diabetes. However its effects in pre
diabetics have not been investigated A randomized placebo controlled trial was conducted to evaluate
the efficacy of zinc supplementation or placebo on fasting blood glucose
levels and homeostasis model assessment
parameters of beta cell function insulin sensitivity and insulin resistance in
pre diabetics over a 6 months treatment period.
Benefits
of Zn suppl No 11:-=Minimizes DM!! FBG and all the HOMA parameters i.e.
beta cell function insulin resistance and insulin sensitivity were
significantly improved with zinc supplementation over 6 months
Benefits
of Zn suppl No 12: Normalizes Lipid profiles !!! At the end of treatment the ratio of
triglycerides and high density lipoprotein was significantly improved in the
intervention group compared to control
The lipid
profile and C reactive protein levels significantly improved in the intervention group compared
to the control group .
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