What
we knew about Zinc and what we should know now about zinc? New information on
Zinc:-Do you
believe that Zinc is an essential micronutrient that plays an important role in
many physiological functions , For instance Zinc act as A) cofactor in over 3000 proteins . B) It directly regulates over 200 enzymes and hormones !!!! C)
it controls growth and cell
renewal . Therefore its deficiency is associated with numerous diseases. It is
important for growth and affects neuronal
, muscular, bone , skin health and also controls immune functions.
Therefore it is no surprise that and
its deficiency increases the
predisposition to infections . Physiological Action and
pathophysiology
The
pleiotropic and complex interactions of zinc affect multiple physiological
functions and its deficiency can inhibit growth compromise the immune and
nervous system and affect all other organ system
An optimum
level of food & serum Zn improves pregnancy outcomes as well as bone skin
and eye health of newborns.
How many members
are aware that as many as A) 20% of the
global population suffers from a zinc deficiency , One will be surprised to
know that many such men & women are at developing countries . AS a matter of fact
those who exhibited low serum Zn in them as many as 61% of the population is at
an increased risk of low dietary zinc intake . Zn in diet & blood is so
relevant that few of the unexplained child mortality and disability may be due
to Zn Deficincy alone .Its deficiency in
infants and children can affect growth and mental functions and cause adolescent nutritional dwarfism.
The
untold story of a micronutrient?? How to combat
presumed Zn deficiency & prevent TDM?? ? Universal Zn supplementation like universal
iodine suppl in India?? Or else should we estimate serum Zn in all Indian population
(population based screening in India) then consider Zn containing tablets. If
that stands scientifically then too Q of finance comes in. Who will pay &
how sensitive is the Zn test !!!). It’s
a mad mans thought. But the fact remains that in men & women with low serum
Zn conc , if supplementation of zinc is
initiated as multivitamin containg high Zn then such suppl can improve a number of diseases
such as unexplained subfertility , respiratory infections, cardiovascular
diseases , diabetes, cancer and mental
health disorders..
Epidemiology and
risk factors
The
recommended daily allowance of zinc
is 15 mg for a male adult that can be achieved through diet. However it
has been reported. In India an overall zinc deficiency of 43.8% was reported ..
Deficiency rates of 49.4% in adolescent girls 52% in non pregnant woman and
64.6% in pregnant women have been observed.
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