What is
letrozole “The Queen of Aromatase inhibitors” : What was the original indication? Ans:-
Letrozole is an oral non-steroidal aromatase inhibitor approved by US
Food and Drug Administration ( FDA) for the adjuvant treatment
of postmenopausal women with
hormone receptor positive early breast cancer.
Off-label it has been used for ovarian stimulation in assisted reproduction
since 2001 and later it was banned in some courtiers as the Queen was in love
with some other gentleman and this is not approved in the ethics and of late religion
in our country!!! .
What happened
in the new century ? Defamation of Queen:- She is bad unkind Queen,
Ban her !!! Few researchers misguided the entire world that letrozole was
associated with increased risks of birth defects and was therefore banned as ovulation induction in many
countries including India since 2011, following reports of 2 studies
citing increase incidences of congenital malformations (locomotor and cardiac
abnormalities).
Did U K listened to such defamation of our
Lady Queen(Letrozole)?? One such study was presented at the American
Society of Reproductive
Medicine 2005 Conference. But, such off-label use
of Letrozole for ovarian stimulation was not declared illegal
in USA and UK. It was continued to be used as
an ovulation induction agent in ARTs Exciting developments: To
their surprise they observed that Letrozole induced ART pregnancies
had 1) risk of miscarriage,2) with no increase in the risk of major
congenital anomalies or 3) adverse
pregnancy or 4) neonatal outcomes
compared with natural cycles in women undergoing ART!!!
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