Ovarian Dysfunction and Amenorrhoea
During the reproductive age, the normal cyclic function
of the ovary is characterised by recruitment of the follicular cohort,
selection of the dominant follicle, ovulation with consecutive corpus luteum
formation, corpus luteum function and the final regression of the corpus
luteum. In this cycle, the central nervous system, the limbic system, the
hypothalamus, the hypophysis and the ovary are partners. Disturbances of these
interactions lead to ovarian dysfunction with follicular maturation
disturbances, inadequate ovulation and inadequate functioning of the corpus
luteum. The resulting bleeding abnormalities (poly-, oligo- or amenorrhoea and also pre, intra and post-ovulatory
bleeding) have to be treated separately. The 1973 WHO classification of ovarian dysfunction still
gives the best general idea of diagnostic techniques and therapy .According to
this classification, amenorrhoea may be the consequence of an ovarian
insufficiency (group 2b), an anatomically caused amenorrhoea (group 4),
hyperprolactinemia (groups 5 and 6) or a non-increase in gonadotropins (group
1). The pathophysiology reveals a lack of stimulation of the hypophyseal
gonadotropin secretion. Groups 3 and 7 comprise patients with hypergonadotropic
ovarian insufficiency.
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