Can a
woman with very low amh ( lower than 0.7 pmol/l) in hypo gonadotropin
hypogonadic female have own baby with her own egg? : How to proceed for ovulation induction in
such cases ?
A)
Scope
1:- Can we initially offer Oestrogen?? Is there any trophic role of estrogen? Some
researchers have claimed that if oestrogen is supplemented in cases of HH( hypo gonadotropin
hypogonadic female ) then
AMH can rise. At least researchers claim
like that . They claim that priming with
any gonadal steroid be it estrgen, androgen
or LH can in casses of hypo gonadotropin hypogonadic ) help to function the population of antral and pre antral follicles .As such AMH
can rise. In these cases pool is too immature to secrete amh. Priming with
estrogen for 3 to 6 months will improve the ovarian volume and also one can start seeing the antral follicles by USG.
Antral
and pre antral follicles are the AMH producing follicles population. But
another group claims that it has to be primed with gonadotropins. The
physiological reset of gonadostat has to be done artificially in hypo gonadotropin
hypogonadic female.. But
ovarian failure, dysgenesis has to be ruled out. In cases of normal puberty initially
hormones like fsh and lh are high and amh is low in prepubertal age. The
initial gonadostat has to be reset
B)
physiological.
An hallmark of puberty where the FSH LH levels come within reproductive range.
Now amh is secreted by preantral follicle and not by immature primary oocyte
level These immature primary oocyte needs to triggered in hypo hypo and that's
a very difficult task .
AMH and
gonadotropins are two different subset of markers of female reproduction. In a
case of hypogonadotropic hypogonadism gonadotropins correlate with intactness of hypothalamic pituitary axis,
but AMH is a denominator of
ovarian function in terms of the existent pool of pre-antral and natural
follicles . Some tiny antral and pre antral follicles often escapes hide
in imaging process and become evident later. AMH slowly rises if gonadotrophins
are administered. Well, in Hypo hypo case, the uterus usually is so small that
most of gynaecologits would have primed them sufficiently with E+/- P for
sometime to get a better uterine size
In the
case of hypogonadotropic hypogonadism hypog waiting for becoming sensitive to
FSH. of functional amenorrhoea( read hypothalamic) this pool is intact so is
the AMH . Scientists are not clear and the matter of rise of AMH after gonadotropins Inj is still debatable & so also rise of AMH levels or is it an inherent coexisting
defect which is affecting the hypothalamopitutary axis as well as the
follicular pool.
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