What will be the long term therapy
for survivors of Peripartum cardiomyopathy ??
Ans:-In long standing cases : say after 2-3 weeks after however recovery :-A) Thromboprophylaxis
Anticoagulants are mandatory if there is severe impaired left ventricular dysfunction
intracardiac thrombus or arrhythmias. B) To continue Conventional treatment for
heart failure including diuretics vasodilators cardio selective B blockers or B blockers with arteriolar
vasodilating action digoxin inotropes and C) after delivery angiotensin
converting enzyme inhibitors. D) Immunosppressivse therapy may be considered in
cases with myocarditis documented by endomyocardial biopsy that fail to improve
within 2 weeks of initiation of standard heart failure therapy .E) Bromocriptine has been suggested in view of
the link with a pathogenic form of prolactin
F) .Intra – aortic balloon pumps and left ventricular assist devices may
provide temporary support. F) Though seem ridiculous for me (an obstetrician
but there has been occasions where in Prepartum cardiomyopathy eventually got
cured by Cardiac transplantation . Case
reports are there . Prognosis and recurrence .Maternal mortality rate has
decreased from 40% in older studies to 9% -15% in more recent series. One study
documented a 95% 5 year survival. Many case fatalities occur close to
presentation and cardiomyopathy causes about 25% of cardiac maternal deaths in
the united Kingdom. About 50% of patients make a spontaneous and full
recovery.Prognosis depends on normalization of left ventricular size and
function within 6 months after delivery . Mortality is increased in those with
persistent left ventricular dysfunction. Women should be counselled against
further pregnancy if left ventricular size or function does not return to normal
since there is a significant risk of recurrence worsening heart failure and
death in subsequent pregnancies. Adequate contraception should be advised such
as the intrauterine progestogen only system or the subdermal progestogen only
implant .For those whose cardiomyopathy resolves. The recurrence risk is not
known but appears to be lower . However the contractile reserves may be
impaired echocardiogram may be appropriate pre- pregnancy .Subsequent
pregnancies are high risk and require
collaborative care
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