Can microdeletion of Y chromosome be a cause of Rec Preg Losss ??

Microdeletion of sperm producing Y chromosome –as a cause of RPL  --- Is is a dream or reality??

It is worth remembering that Different   micro deletions have deleterious  effects  in different  aspects   of male fertility More informations  on Microdeletion of  a segment of long arm of Y chromosome . That particular segment i.e. –the long arm segment contains many loci (full of genes ) whose duty  is entrusted for  sperm production,.  Micro deletions of the chromosome Y long arm are the most frequent molecular   genetics of severe   male infertility , mainly   by presence of   severe oligozoospermia and non obstructive azoospermia . Nowadays   these genetic    alterations could be screened   as routine   which is important since  they are present  in approximately in 9% of the oligo azoospermia males.

At the molecular   level   Y chromosome  micro deletions affect at least three regions known   as azoospermia factor    these  three regions  are essential   for a   successful spermatogenesis.. It is of note though   the AFZ cv 2/64   deletions since men carrying   them produce    a higher percentage   of nullisomy for the sex    chromosome   and NY   disomy  .

Query to learned members: Can there be   a link between male   carriers of Y  chromosome    deletions and RPL(Rec Preg losses) ?? I don’t know. Any member like to volunteer pl??    . In fact Dewan et al in 2006  observed that in couples  with RPL  a significant percentage   of the  males   had chromosome Y  micro deletions . Another   study   carried out by Agarwal et al in 2015   stated that in couples suffering  RPL  32.5% of males  were carriers of chromosome Y  micro deletions  and after excluding  the female  factor  in 13. 5%   of the cases. Interestingly the most  frequent   micro deletion was the AZFc.  The incidence of    chromosome Y   micro deletion   is different in different  population    since is linked  to chromosome  Y  haplogroups  . In fact Venkatesh et al   did not  detect   any micro deletion  in a population of RPL  in New Delhi.

Nevertheless taking  in account  the population  that one is dealing the prevalence of microdeletion as an cause of RPL may vary . Is that also the members opinion. PL share your views This will be a later date which will offer a relationship of AZF deletions and its etiology as RPL besides cong thrombophilia and  other genetic causes of Post embryonic growth & development aberrations. A day may come when we the treating gynecologist  may ask cases of RPL for AZF deletion in male partner . Till then let’s hope that that micro deletions in chromosome Y   may not be a  cause  of RPL  so that

The unfortunate male is exempted from study    of such    chromosomal   abnormalities   in cases of RPL & idiopathic abortion