Brest cancer which cant be modified by the woman concerned not to repent

What are the unmodifiable factors in genesis of Br Ca?? Breast Cancer Risk Factors one Cannot Change

A risk factor is anything that increases ones chances of getting a disease, such as breast cancer. But having a risk factor, or even many, does not mean that she  will  sure to get the disease. Some risk factors for breast cancer are things one  cannot change, such as getting older or inheriting certain gene changes. These make ones risk of breast cancer higher.

1) Age 2) Inheriting certain gene changes

About 5% to 10% of breast cancer cases are thought to be hereditary, meaning that they result directly from gene changes (mutations) passed on from a parent.

2) Family history  of breast cancer

It’s important to note that most women who get breast cancer do not have a family history of the disease. But women who have close blood relatives with breast cancer have a higher risk:

·         Having a first-degree relative (mother, sister, or daughter) with breast cancer almost doubles a woman’s risk. Having 2 first-degree relatives increases her risk about 3-fold.

·         Women with a father or brother who has had breast cancer also have a higher risk of breast cancer.

Overall, about 15% of women with breast cancer have a family member with this disease.

4)                     Having a personal history of breast cancer

A woman with cancer in one breast has a higher risk of developing a new cancer in the other breast or in another part of the same breast. (This is different from a recurrence or return of the first cancer.) Although this risk is low overall, it's even higher for younger women with breast cancer.

5)                     race and ethnicity

Overall, white women are slightly more likely to develop breast cancer than African-American women, although the gap between them has been closing in recent years. In women under age 45, breast cancer is more common in African-American women. African-American women are also more likely to die from breast cancer at any age. Asian, Hispanic, and Native American women have a lower risk of developing and dying from breast cancer.

Risk in different groups also varies by type of breast cancer. For example, African-American women are more likely to have the less common triple-negative breast cancer.

6)                     Being taller

Many studies have found that taller women have a higher risk of breast cancer than shorter women. The reasons for this aren’t exactly clear, but it may have something to do with factors that affect early growth, such as nutrition early in life, as well as hormonal or genetic factors.

7)                     Having dense breast tissue

Breasts are made up of fatty tissue, fibrous tissue, and glandular tissue. Breasts appear denser on a mammogram when they have more glandular and fibrous tissue and less fatty tissue. Women with dense breasts on mammogram have a risk of breast cancer that is about 1 1/2 to 2 times that of women with average breast density. Unfortunately, dense breast tissue can also make it harder to see cancers on mammograms.

A number of factors can affect breast density, such as age, menopausal status, the use of certain drugs (including menopausal hormone therapy), pregnancy, and genetics.

To learn more, see our information on breast density and mammograms.

8)                     Having certain benign breast conditions

Women diagnosed with certain benign (non-cancer) breast conditions may have a higher risk of breast cancer. Some of these conditions are more closely linked to breast cancer risk than others. Doctors often divide benign breast conditions into 3 groups, depending on how they affect this risk.

Non-proliferative lesions: These conditions don’t seem to affect breast cancer risk, or if they do, the increase in risk is very small. They include:

·         Fibrosis and/or simple cysts (sometimes called fibrocystic changes or disease)

·         Mild hyperplasia

·         Adenosis (non-sclerosing)

·         Phyllodes tumor (benign)

·         A single papilloma

·         Fat necrosis

·         Duct ectasia

·         Periductal fibrosis

·         Squamous and apocrine metaplasia

·         Epithelial-related calcifications

·         Other tumors (lipoma, hamartoma, hemangioma, neurofibroma, adenomyoepithelioma)

Mastitis (infection of the breast) is not a tumor and does not increase the risk of breast cancer.

Proliferative lesions without atypia (cell abnormalities): In these conditions there’s excessive growth of cells in the ducts or lobules of the breast, but the cells don't look very abnormal. These conditions seem to raise a woman’s risk of breast cancer slightly. They include:

·         Usual ductal hyperplasia (without atypia)

·         Fibroadenoma

·         Sclerosing adenosis

·         Several papillomas (called papillomatosis)

·         Radial scar

Proliferative lesions with atypia: In these conditions, the cells in the ducts or lobules of the breast tissue grow excessively, and some of them no longer look normal. These types of lesions include:

·         Atypical ductal hyperplasia (ADH)

·         Atypical lobular hyperplasia (ALH)

Breast cancer risk is about 4 to 5 times higher than normal in women with these changes. If a woman also has a family history of breast cancer and either hyperplasia or atypical hyperplasia, she has an even higher risk of breast cancer. Early menarche : Starting menstrual periods early

Women who have had more menstrual cycles because they started menstruating early (especially before age 12) have a slightly higher risk of breast cancer. The increase in risk may be due to a longer lifetime exposure to the hormones estrogen and progesterone.

Late menopause  Going through menopause after age 55yrs

Women who have had more menstrual cycles because they went through menopause later (after age 55) have a slightly higher risk of breast cancer. The increase in risk may be because they have a longer lifetime exposure to the hormones estrogen and progesterone.

Having radiation to chest

Women who were treated with radiation therapy to the chest for another cancer (such as Hodgkin or non-Hodgkin lymphoma) when they were younger have a significantly higher risk for breast cancer. This risk depends on their age when they got radiation. The risk is highest for women who had radiation as a teen or young adult, when the breasts are still developing. Radiation treatment in older women (after about age 40 to 45) does not seem to increase breast cancer risk.

What are Lobular carcinoma in situ (LCIS)??

In LCIS, cells that look like cancer cells are growing in the lobules of the milk-producing glands of the breast, but they are not growing through the wall of the lobules. LCIS is not considered to be cancer, and it typically does not spread beyond the lobule (become invasive breast cancer) if it isn’t treated. But women with LCIS have a 7 to 12 times higher risk of developing breast cancer (which can be in either breast).