Myoinositol in PCO

Now coming into the role -Inositol & PCO:_PCOS in most cases , but not in all women is characterized by reduced levels  of inositol . Arre we aweare of this?

Evidences suggest that a deficiency of  inositol  contribute  to insulin  resistance   in PCOS individuals  . It was observed that  deficiency  of inositol   shows   defective  insulin  signaling  pathway  in patients with PCOS. The  women with PCOS   and normal    women were assessed for circulating   inositol  and 24 hr urinary clearance of inositol  and insulin sensitivity . The findings  indicated a marked   alteration in inositol  urinary  clearance    and deficient insulin stimulated PI 3 kinase release in PCOS   women.

Plasma   concentrations of inositol is  significantly lower in PCOS  women compared  with normal control   subjects   consequently  urinary  clearance of Inositol was  significantly  higher  in
CPOS women   compared with normal  control    subjects .

Increased urinary  clearance   of inositol is an independent predictor of insulin  resistance in PCOS patients

Consequently AUC inositol was significantly  lower in PCOS women compared with normal   control  subjects

These  findings strongly suggest a contribution of abnormal  metabolism of inositol to the insulin resistance in PCOS patient   which leads to a reduction in circulating   inositol and its availability  to the  tissues . Finally in conclusion  a defect in  tissue availability of inositol in PCOS contributes  to the  insulin resistance     leading to decreased  cellular  availability of the PI 3 kinase  mediated  insulin action.

Theory 3: Altered   insulin signaling and its relationship with IR and PCOS. 

PI 3  kinase is a mediator for glucose metabolism and  its utilization by the cell.

Deficiency of inositol alters  activity of PI3  kinase.

Reduced activity of PI 3 kinase  reduces  translocation of GLUT 4 thereby causing  hyperglycemia 

This brings about  altered  insulin  signaling causing  hyperinsulinemia   and   thus IR . Insulin resistance   thus is  responsible for PCOS. 

Pathway of inositol  deficiency and PCOS 

Metformin fails to manage Insulin Resistance in PCOS women

Metformin  is the most  commonly prescribed insulin   sensitizing drug  in the treatment   of PCOS. It  enhances insulin sensitivity   by activating PI 3   kinase  but it has been postulated  that Metformin has  a very restrictive mechanism of action due to which  it is not  a right  treatment   option for PCOS. How useful is metformin??Authentic journal statements  on the use of  metformin in PCOS 

In the absence of large  adequately powered placebo controlled trials  it is   difficult   to provide useful answers   about the longer  term   benefits  of metformin in PCOS women. However   there are more   side effects  with metformin  like lactic acidosis and malabsorption  including  poor adsorption of vitamin B12

Thus there arises a therapy which  cares  for each and every symptom of PCOS along with documented  safety.