Wednesday, 15 April 2020

Gene dependent Cancers- Proto oncogenes & breast cancer prevention : Mismatch repair gens


The goal keeper Gens which prevents goals even from penalty kick:: Healthy genes protect from many a cancers including Breast Cancer : The role of friendly genes (the goal keeper)  to control and quickly repair any mismatch  DNA  in the concerned  cell factory . The  role Proto-oncogenes My dear Membes please do remember that  most cancer-causing mutations involving oncogenes are acquired, not inherited. They generally activate oncogenes by some environmental process or by ones poor life style. Not to blame your parents unnecessarily :
Proto-oncogenes are genes that help cells grow normally. But problem arises when a proto-oncogene mutates (changes) or there are too many copies of it, it becomes a "bad" gene that can stay turned on or activated when it’s not supposed to be. When this happens, the cell grows out of control and makes more cells that grow out of control. This can lead to cancer. This bad gene is called an oncogene
It may be helpful to think of a cell as a car. For it to work properly, there need to be ways to control how fast it goes. A proto-oncogene normally functions in a way that is much like a gas pedal. It helps the cell grow and divide. An oncogene could be compared with a gas pedal that is stuck down, which causes the cell to divide out of control.A few cancer syndromes are caused by inherited mutations of proto-oncogenes that cause the oncogene to get upper hand and it itself  turned on (activated). But most cancer-causing mutations involving oncogenes are acquired, not inherited. They generally activate oncogenes by:
·         Chromosome rearrangements: Changes in chromosomes that put one gene next to another, which allows one gene to activate the other
Gene duplication: Having extra copies of a gene, which can lead to it making too much of a certain protein 
·         GENES AND CANCER
Oncogenes and tumor suppressor genes
Two of the main types of genes that play a role in cancer are A) oncogenes (corona type) and B) tumor suppressor genes( Antimalarials chloroquine)
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