Spermatogensis -its hormonal control

Hormonal control of spermatogensis.

Hormone nature of origin function molecule

1 GnRH(LHRH) It is Decapeptide in nature, Source is Hypothalamus Acts on pituitary gland to secrete FSH and LH.

2 FSH : nature:---Glycoprotein : Source is pituitary gland Acts on Sertoli cells. Sertoli cells produce inhibin and also initiates spermatogenesis.

3 LH is Glycoprotein in nature, Source is pituitary gland :: Stimulated Leydig cells, which produce testosterone and maintain spermatogenesis

4 Prolactin Nature is Polypeptide Source is Pituitary (adenohypophysis) Mode of action:- Accentuates the LH effect on Leydig cells.

5 Testosterone : Chemical nature is steroid : source is Leydig cells : Effect is :maintenance of spermatogenesis. it also acts as a prohormone for estriol (E-2) and dihydrotestosterone.

6 Estrogen Chemical nature is steroid extraglandular: Source is : . Fat , Liver and muscle tissue

by aromatization of testosterone and

androstendione. Mode of action:-- regulation of LH secretion.

7 inhibin : source is from Sertoli cells : Function: is inhibition of pituitary FSH secretion and it is also a Glycoprotein in nature.

8 activin is from Leydig cells Chemical nature is Glycoprotein acts on simulation of pituitary FSH secretion

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