LH hormones which leads to rupture of follicle, ovulation and pregnancy is not a servant of any kind of progesterone!!!! My granddaughters do not listen to me when I ask them not to smoke / talk to boyfriends They sometimes dont listen to me. .LH, similarly may sometimes dont obey the order of exogenous progesterone? If that be so then , what is the prevalence of ESCAPE OVULATION in spite of regular ingestion of COC with adequate progesterone. Who is the ancestor of progesterone. Don’t be afraid .,It is not for NRC?/ NCA !!! Evolution of Progesterones ::-History of progestins selection oral contraceptive drugs and their use :-
The first hormonal pill, called Enovid, was approved by the Federal Drug Administration (FDA) in May 1960. It contained mestranol and norethisterone. Over the years, oral contraceptives have evolved through gradual lowering of ethinyl estradiol (EE) content, introduction of 17β estradiol, and many different progestins. The standard regimen allows for 21 days of pill containing steroids and a pill-free interval of 7 days. Recently, continuous or extended regimens have been approved. In order to improve compliance, alternative routes of combined oral contraceptive (COC) administration have been developed such as vaginal or transdermal routes.
In 2009, according to the United Nations, the mean global percentage using contraception in women who are married or in union was 62.7%. COC represented 8.8% of contraceptive prevalence, reaching 15.4% in more developed countries. More than 100 million women worldwide use COCs. However, each year, many unintended pregnancies occur, indicating that contraception still needs to be updated =Mistaken pills/Missed pills/Surprised preg due to escape ovulation.. Progesterone is the chief drug which cause contraception,. The contraceptive efficacy is primarily due to LH suppression and prevents ovulation. act cause LH suppression, But LH dis not be considered as a servant of progesterone . So pill failure continues to occur.
The first hormonal pill, called Enovid, was approved by the Federal Drug Administration (FDA) in May 1960. It contained mestranol and norethisterone. Over the years, oral contraceptives have evolved through gradual lowering of ethinyl estradiol (EE) content, introduction of 17β estradiol, and many different progestins. The standard regimen allows for 21 days of pill containing steroids and a pill-free interval of 7 days. Recently, continuous or extended regimens have been approved. In order to improve compliance, alternative routes of combined oral contraceptive (COC) administration have been developed such as vaginal or transdermal routes.
In 2009, according to the United Nations, the mean global percentage using contraception in women who are married or in union was 62.7%. COC represented 8.8% of contraceptive prevalence, reaching 15.4% in more developed countries. More than 100 million women worldwide use COCs. However, each year, many unintended pregnancies occur, indicating that contraception still needs to be updated =Mistaken pills/Missed pills/Surprised preg due to escape ovulation.. Progesterone is the chief drug which cause contraception,. The contraceptive efficacy is primarily due to LH suppression and prevents ovulation. act cause LH suppression, But LH dis not be considered as a servant of progesterone . So pill failure continues to occur.
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