What is PIBF IN PREGNANCY??

Why progesterone in Thr abortion or RPL or say Thr Preterm labour? What is the explanation? How does progesterone does work??

How rational it is to prescribe Progesterone ,which is costly drug taken for the long time at least for Indian people or pushed vaginally for long duration . The very dea of Progesterone suppl is  to down regulate the so called presumed excess (unproven presumption in the concerned as not estimated)  “ pro-inflammatory cytokines and/or to up regulate anti-inflammatory cytokines in cases of P/H/O idiopathic abortion or idiopathic spont abortion??

What do Membes do/ their considetd opinion??> Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery.

Raghupathy R¹, Al-Mutawa E, Al-Azemi M, Makhseed M, Azizieh F, Szekeres-Bartho J.

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Abstract

Spontaneous miscarriage and preterm delivery are common complications of pregnancy. Pro-inflammatory cytokines have been shown to be associated with recurrent spontaneous miscarriage (RSM) and preterm delivery (PTD) and these have led to exploration of ways to downregulated pro-inflammatory cytokines and/or to upregulated anti-inflammatory cytokines. Progesterone-induced blocking factor (PIBF) is a molecule with inhibitory effects on cell-mediated immune reactions. We have ascertained the effects of PIBF on secretion of selected type 1 and type 2 cytokines by peripheral blood mononuclear cells from healthy non-pregnant women, women undergoing normal pregnancy, women with unexplained RSM and women with PTD. Peripheral blood mononuclear cells from 30 women with a history of unexplained RSM, 18 women undergoing PTD, 11 women with normal pregnancy and 13 non-pregnant healthy women were stimulated with a mitogenic in the absence and presence of PIBF after which the levels of cytokines released into culture supernatants were determined by ELISA. Production of the type 2 cytokines IL-4, IL-6 and IL-10 by lymphocytes from the RSM and PTD groups and of IL-4 and IL-10 by lymphocytes from healthy pregnant women was significantly increased upon exposure to PIBF, while the levels of type 1 cytokines were not affected. Ratios of type 1:type 2 cytokines were decreased, suggesting a shift towards Th2 bias. PIBF did not affect cytokine production by lymphocytes from non-pregnant women. Thus, PIBF acts on lymphocytes in pregnancy to induce a type 1 to type 2 cytokine shift by upregulating the production of type 2 cytokines.

PMID:

19371956

[Pub Med - indexed for MEDLINE]