Thursday, 28 May 2020

Corpus luteum cyst ,its ruptutre or leaks


Corpus Luteum and Theca Lutein Cysts


  Warfarin in reproductive age-can it cause leaking C L : Any member have ever witnessed any case of C L cyst rupture/ continued leak from recently ruptured Dominat follicle or say Corpus Luteum Cysts in any women reproductive age who are on blood thinners??

Q.1:   What is a Corpus luteum?? This is a kind  of physiologic or functional cyst is known as a corpus luteum cyst (CL Cyst). These are less frequent than a follicular cyst but can cause more problems and emergencies, especially internal bleeding. Why do you need to know the difference? Because we have to distinguish between these cysts and other  cysts and the  specific dangers and treatment options. These cysts also produce different hormones that affect your body and hormone balance. Such cysts as expected be observed in early  pregnancy, which is perfectly normal. Such preg associated C L cysts usually go away by the second trimester. Some do not, and if they do not look suspicious on the ultrasound, it is safe to leave them alone. In most cases, they eventually go away after pregnancy.
Q.2:-Why we should consider CL cyst rupture as more or less  as an physiologic event ?? Ans: Each month, a mature ovarian follicle ruptures, releasing an ovum so the process of fertilization can begin. Occasionally, these follicles may bleed into the ovary, causing cortical stretch and pain, or at the rupture site following ovulation. Similarly, a corpus luteum cyst may bleed subsequent to ovulation or in early pregnancy. As blood accumulates in the peritoneal cavity, abdominal pain and signs of intravascular volume depletion may arise. Problem arises when there is excessive bleeding .Quite often the  etilogy of this increased bleeding is unknown, although abdominal trauma and anticoagulation treatments may increase the risk.
Q.3 What is the etiogenesis of persistence of CL cyst or say rupture of a C L cyst ?  What is the pathophysiology and prognosis of C L cysts?
 Complications of C L cyst / rupture : No 1:-. Most cases where rupture of C.L. cyst occurs the consequences of cyst ruptures are self-limiting, requiring only expectant management and oral analgesics for relief of abdominal pain. Duration of symptoms varies from a few days to several weeks and may depend, in part, on the type (hemorrhagic vs nonhemorrhagic) and volume of cyst fluid in the pelvis. The patient often presents with an acute onset of abdominal pain, typically during strenuous physical activity, such as exercise or sexual intercourse. Given that follicular cyst rupture is more common than corpus luteal cyst rupture, the onset tends to be midcycle. Other associated symptoms include the following:
Although circulatory collapse, hemorrhagic shock, disseminated intravascular coagulation (DIC), and death have been reported, these are quite rare.

Q. 4 : Symptoms of C L cyst rupture or contd leaking??
·        Vaginal bleeding, Nausea and/or vomiting
·        Weakness
·        Syncope
·        Shoulder tenderness

Circulatory collapse/.

 

Q.5: Outcome of C L cysts rupture?? The most pressing issues facing clinicians encountering patients with potential cyst rupture in the acute setting are to rule out ectopic pregnancy, ensure adequate pain control, and rapidly assess the patient for hemodynamic instability to allow appropriate triage. Although most patients require only observation, some need analgesics for pain control and laparoscopy or laparotomy for diagnosis or to achieve hemostasis. By the way, pelvic pain with or without ovarian cysts being present does not mean the pain is coming from a gynaecologic organ. In other words, there are other things down there in your pelvis. You could have appendicitis or other bowel problems, which have nothing to do with your gynaecologic organs. If surgery is necessary because of bleeding, it is often possible to do it through a laparoscope (band aid surgery). Usually the ovary does not have to be removed. Only the cyst is removed and bleeding stopped.


Q.6: How does a rupture of CL  clinically present?? Ans: It often mimick ectopic as sometimes progesterone don’t decrease in time(continued secretion of Progesterone from C L ) . As such there is delay in period in spite  of being nonpregnant . So both EP & CL may present as missed period followed by some spotting, one-sided pelvic pain and a pelvic examination, which finds a tender ovarian mass, suggest that a persistent either Ectopic or Corpus Luteal cyst . These are the two most common diag which one should keep in mind possible diagnois but one should be cautious about C L Cyst rupture. . It is important to make sure, however, that a pregnancy test is ordered, because these same findings may be there for an ectopic pregnancy (tubal pregnancy). An ultrasound may not be able to tell these two apart and the treatment would be completely different. There is another no physiologic cyst, which can cause similar symptoms, called an "endometrioma" that one (specially sonologist)  need to be familiar with. That is treated in yet another way, often involving surgery, and is a whole separate topic.

 

 

 

Q. 7: Can there be rupture of a pathological, cyst in mid menst period and can confuse us?? Ans: Not impossible either. Such no physiologic cysts are  cystadenoma and mature cystic teratoma (dermoid cysts),and Thecal L cyst associated  with molar pregancy. Such cysts may, in rare cases, rupture and cause symptoms. In addition to hemorrhage, significant pain can accompany rupture of a dermoid cyst, presumably from spillage of sebaceous fluid, resulting in a diffuse chemical peritonitis. 
Q. 8 : How do you know that your Pt. is  having  a C L  Cyst ? Ans: A ruptured ovarian cyst is a common phenomenon, with presentation ranging from no symptoms to symptoms mimicking an acute abdomen.  Sequelae of CL cyst rupture varies. Menstruating women have rupture of a follicular cyst every cycle, which is either asymptomatic or with mild transient pain (mittelschmerz). In less usual circumstances, the rupture can be associated with significant pain. In very rare circumstances, intraperitoneal hemorrhage and even  death may occur. While some hemorrhage associated with ovarian cyst rupture has unclear etilogy, there are recognized risk factors. These include abdominal trauma and anticoagulation therapy. The condition most commonly occurs in reproductive-aged women of 18-35 years.

 

 

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Q.9: What to expect from Physical Examination??

Vital signs are usually within normal range. Physical findings can range from mild unilateral lower abdominal tenderness to those of an acute abdomen with severe tenderness, guarding, rebound, and peritoneal signs. Low-grade fever is sometimes observed, and an adnexal mass may be palpable, although absence of such findings on examination has no diagnostic value as many cysts decompress after rupture. Orthostatic changes are consistent with a sizable hemorrhage. Abdominal Trauma  can rarely be a predisposing a factor for rupture,
Q. 10 : How to diagnose C L cyst ?? Ultrasonography is the preferred imaging modality for assessing gynecologic structures, given its low cost, availability, and sensitivity in recognizing adnexal cysts and haemoperitoneum. Despite this, there remain instances in which the ultrasound findings are nonspecific, particularly after rupture and decompression of a cyst in the setting of apparent physiologic levels of fluid in the pelvis.
Q. 11:--What then if USG diag / Report is inconclusive?? Ans: CT is the answer. If ultrasound yields ambiguous results in a patient with significant pain, computed tomography (CT) of the pelvis with contrast should be performed. CT features of corpus luteum cysts have been more or less specific.

What is the Role of  culdocentesis as of 2020?? Ans: No .   Although commonly performed in the past, culdocentesis has been largely abandoned in favor of ultrasonography and CT scanning, as both can readily identify fluid collections in the cul-de-sac. Culdocentesis is still acceptable, however, in locations where imaging is not available.

Patients with presumed cyst rupture are typically managed conservatively.
Q. 12 : How to persist or drag conservative treatement of CL?? Ans:-Conservative medical care may consist of outpatient treatment with oral analgesics in the stable patient, or if the clinical picture is evolving, admission and anticipatory management with serial abdominal examinations and laboratory testing, repeat imaging, and pain relief with an analgesic of choice.   Medical therapy consists of appropriate pain relief. Pain relief medications can include acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), narcotics, or an analgesic of choice.
Medications may range from oral acetaminophen to intravenous tramadol, paracetamol, or via patient-controlled analgesia (PCA) infusion pumps. If continued bleeding is a concern or if the patient is unstable haemodynamically, one should proceed with surgery.

Surgical care may entail laparoscopy or laparotomy, depending on clinical presentation, amount of blood in the abdomen, patient stability, and operator skill. Most bleeding can be stopped with suturing, cautery, cystectomy, or wedge resection. Occasionally, salpingo-oophorectomy is necessary.

Q. 13 : What may be the D/D? Ans: Acute app, UTI, pelvic inflammatory disease, renal stone, urereteric colic. Diagnois mainly by imaging and one has to utilize the D/D , as mentioned . 

 

A)                 The possible diag are Ectopics,  appendicitis, Rupture of Dermoid, Solid Ov tumour, UTI, Ureteric colic, Diverticulitis, Renal stone,    If concerned regarding possible hemorrhage, monitor the hematocrit (serially, if necessary) to ensure there is no continued bleeding. 

  Estimate   urine pregnancy test. If the pregnancy test is positive, make sure to rule out an ectopic pregnancy. Evaluate for ovarian torsion before discharge. If a diagnosis of bleeding ruptured ovarian cyst is considered, make sure the haemoglobin level is stable before discharging the patient. It is appropriate to admit the patient for observation and pain control.

Perform a diagnostic laparoscopy and/or laparotomy if the patient is haemodynamically unstable or if a specific diagnosis is unclear, yet a definitive diagnosis is necessary.

Q. 14 : Can there be repeated rupture of CL cyst almost every month??   Ans: Very rare indeed. For the patient with multiple episodes of ruptured physiologic cysts or following a single severe episode, it is reasonable to consider suppression of ovulation with oral hormonal contraception, as this may help reduce the risk of recurrence of ovarian cysts.
Q. 15:-Take home message on C L cyst :Accurate diagnois :-- 1) Serum or urine pregnancy testing should be performed. In the case of a positive result, the patient should be evaluated for ectopic pregnancy. If the diagnosis is unclear, 2) urinalysis should be performed to identify a possible urinary tract infection or renal or bladder stones. 3) Routine :blood, urine, and cervical cultures may also be indicated rule out pelvic inflammatory disease or urinary tract infections.  Blood type and cross-match are indicated in patients with significant peritoneal signs or hemodynamic instability, because such patients may require surgical intervention or blood transfusion.

B)                 Pain control Pain control is essential to quality patient care. These medications ensure patient comfort and have sedating properties, which are beneficial in the treatment of pain. Acetaminophen is the drug of choice for pain in patients with documented hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs; those with upper GI disease; or those who are taking oral anticoagulants.

Morphine sulfate: Not nowadays used. But earlier Morphine sulfate was  the drug of choice for narcotic analgesia, owing to its reliable and predictable effects, safety profile, and ease of reversibility with naloxone. In the decades  of fifties/ Sixties Intravenous morphine  administration may be dosed in a number of ways and commonly is titrated until desired effect is obtained.


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C) Purchase time no jumping for Laparoscopy!!! That is all about non rupture of  CL. But what happens when there is  C  L ruptures, S/S depends on the amount of bleeding and/or pain may cause this to be a surgical emergency. This is unusual, but there are medications ( blood thinners -anticoagulants) that one is taking that could make it much worse. In particular, these include aspirin, non-steroidal anti-inflammatory drugs (e.g. ibuprofen), 
Vitamin E . Therefore  all women reproductive should ideally basically stay away from anything that may "thin the blood" and cause easy bruising or bleeding including vain surfaces , unless specially indicated ? It is duty of doctor to enquire  all the medications, she might be taking .Unfortunately, one third of women (33%) who have a problem with bleeding from a CLC will have it happen again, possibly over and over. So knowing what to avoid can save more than one trip to the operating room or possibly even your life. If the cyst is NOT ruptured, and there is no bleeding or torsion, it is reasonable to avoid surgery and “wait it out." Why? Because surgery, no matter how small, causes scars or adhesions to form.  Doctor should try  to avoid surgery .


What research is due?? How informative is CRP &  plasma D-dimer levels  ?? Ans:  1) A study by Shiite et al indicated that C-reactive protein (CRP) levels can be used preoperatively to differentiate a ruptured ovarian cyst from ovarian torsion. In a retrospective evaluation of 98 patients diagnosed with a benign ovarian cyst, it was found that 21 patients with a ruptured cyst and 77 patients with ovarian torsion had mean preoperative CRP levels of 6.6 and 0.9 mg/dL, respectively; the mean size of the ovarian cysts also differed significantly between the two groups (6.7 cm and 9.7 cm, respectively). The investigators mentioned another study, however, that indicated that patients with ovarian torsion who present over 10 hours after the onset of acute abdomen with elevated CRP levels are at risk of necrosis. They suggested, therefore, that by taking into account imaging findings, CRP levels, and time of acute abdomen onset, clinicians can preoperatively differentiate ovarian cyst rupture from ovarian torsion.
Tanaka et al suggest that plasma D-dimer levels may be markers for endometriotic ovarian cyst rupture. In their study of 6 patients with emergent endometriotic cyst rupture and 16 control patients with unruptured endometriotic cysts, significantly elevated plasma D-dimer levels were seen in the group with the ruptured cysts. The investigators also noted that differences in white blood cell count and serum CRP levels between the two groups were statistically significant.

 

Theca Lutein Cysts


The least common type of physiologic or functional cysts are cal
led "theca lutein cysts" . The key difference is that these are usually multiple, on both ovaries, and occur all at the same time. Each of these cysts can be 1cm to 10cm in size, so if there are multiple cysts, the ovaries can be massively enlarged: up to 20 to 30cm (about 10 inches or more) on both sides.

 

Corpus luteum cyst
Corpus luteum cyst is a type of ovarian cyst which appears after ovulation-extrusion of oocyte along with cumulus. C L may,  fill with fluid or blood, causing the corpus luteum to expand into a cyst, and stay in the ovary. Usually, this cyst is on only one side, and does not produce any symptoms .Occasionally such physiological cyst may rupture at any time after ovulation. By and large C L cyst is of considerable size may  take up to three months to disappear entirely. A corpus luteum cyst usually cant occurs after menopause. Corpus luteum cysts may contain blood and other fluids. The ruptured follicle begins producing large quantities of estrogen and progesterone in preparation. The physical shape of a corpus luteum cyst may appear as an enlargement of the ovary itself, rather than a distinct mass -like growth on the surface of the ovary.
In women of reproductive age cysts with a diameter of less than 5 cm are common, clinically inconsequential, and almost always a physiological condition rather than a cancer or other disease condition. What can be the largest possible size of normal CL?? Ans:-It can, however, grow to almost 10 cm (4 inches) in diameter and has the potential to bleed into itself or twist the ovary, causing pelvic or abdominal pain. If it fills with blood, the cyst may rupture, causing internal bleeding and sharp pain. This pain disappears within a few days of the rupture. Rarely, it may cause the ovary to twist around the ovarian ligament and can cut off the blood flow to the ovary. This is known as ovarian torsion and causes pain and other symptoms In postmenopausal women the threshold for concern is 1 cm. Any cyst > 10 mm in psmeno should be viewed with concern .  Although ovarian cancer is cystic, it does not arise from benign corpus luteum cysts. Medical specialty professional organizations recommend no follow-up imaging for cysts which are clinical inconsequential.
https://upload.wikimedia.org/wikipedia/commons/thumb/6/69/Corpus_luteum_cyst_with_bleeding.jpg/220px-Corpus_luteum_cyst_with_bleeding.jpg

Corpus luteum cyst with bleeding, whereof fresh blood is visualized as anechoic (dark), with a protrusion of coagulated blood is seen in top part of image. Theca Lutein Cysts


The least common type of physiologic or functional cysts are cal
led "theca lutein cysts" . The key difference is that these are usually multiple, on both ovaries, and occur all at the same time. Each of these cysts can be 1cm to 10cm in size, so if there are multiple cysts, the ovaries can be massively enlarged: up to 20 to 30cm (about 10 inches or more) on both sides. Etiology of Theca Lutein Cysts??

  How does this happen? Ans: This is the answer is simply hormonal overstimulation of the ovaries due to pregnancy. Most often this occurs due to very high beta-hCG levels (a hormone of pregnancy) often seen with twins or abnormalities called "molar pregnancy," where the placenta develops but the fetus does not. This is a highly oversimplified explanation, but the point is that high levels of hCG stimulate the ovary. The reason for this overstimulation should be evaluated. Sometimes these cysts can even look like cancer to the untrained eye. Quite a scare, but usually you just need to ask the right questions and in most cases it is not cancer.

Wednesday, 27 May 2020

Enclomiphene -how useful it is?


Q.1:-  When  given choice will you prescribe clomiphene or only active agent as Enclomiphene  ? I understand that many a clinician are biased for those drugs to which she/ he is comfortable or familiar for years together . By contrast there is another group of energetic ,possibly more academic clinicians who  accept  any new drug too quickly before robust data are available,

Who is  your friend - Enclomiphene and Zuclomiphene ??  Ans:-Enclomiphene and Zuclomiphene which e is best ?? Few pharma company  have come up with  Enclomiphene Only —
Q.2:-Enclomiphene Only —why?? Logic:-Clomiphene citrate is a racemic mixture of stereoisomers, Enclomiphene and Zuclomiphene in the ratio of 62% : 38%.
We have to  remember that enclomiphene is the one primarily responsible for ovulation induction, while zuclomiphene is the one primarily responsible for negative effects.
 This  basic informations on pharmaco chemistry prompted many gynaecologists  to prescribe the active pure isomer of clomiphene citrate viz. Enclomiphene for ovulation induction
Q.3: What are the negative  effects with clomiphene citrate if combined form is used?? Ans:- The negative effects commonly encountered are 1)  endometrial thinning in 15-50% of patients, 2) poor cervical mucus and 3) CC  resistance in 15-40% of cases.
Q. 4:--,1:-What is Clomiphene resistance Ans: No ovulation inspite of higher dose of CC.    By contras CC Failure implies:--Ovulation but no pregnancy=(the presumable causes of contd infertility inspite of documented ovulation lliculomeytry) & serum progesterone on day 21-22 is reassuring still no pregancy may be frusta .
Q. 5:-- Causes of CC failure? Why do women fail  conceive despite ovulation??
The known causes of failure to conceive I CC cycle despite documented ovulation are  1)Thin endometrium 2) short implantation window in CC cycles 3) Poor  oocyte quality  due to  persistent high androgens inside  the Liquor Folliculi  in PCO cases 6) Less favourvbale growth factors in granulosa cells I  CC  cycles and sanity receptor induction  in Endometrium.

Q. 6: -CC is ne part but followings are also important like a) Correction of Stress/ daily brisk walking & Exercise/ Eating healthy diets and avoiding street foods and oily foods, Correction  of  elevated PRL,TSH, and insulin by metformin or myoinositol.
Q. 7 : What will be the treatement of C Resistance. The options are 1) May be   letrozole only or with  adjuncts like Myo inositol 2-4 Gm Oc or Metformin 2000mg in divided doses or   2) Letrozole flowed by gonadotrophins from cycle day 8 to day 12 as needed inj hMG(cheap urinary will achieve identical  success) may be tried if age < 27yrs and trying time is < 4 yrs,  3) Drilling. if LH>12 on  day 3of spont cycles & large volumes of  ovaries like > 12 ml
Q. 8:-” If she does not agree for LOD or there are indefinite/ suboptimal indications of LOD  and to add to the problem the alternative agent or protocol of ovulation induction is Chr low dose protocol. then   proceed for Low dose step up R-FSH 50 units till follicular recruitment is visible then maintain that dose & increase if no recruitment.
Q. 9:-Is there any role of CC in Male Subfertility.
Testicular causes:- Male hypogonadism is one of the major reasons of male infertility. About 30 % male factor subfertility suffer from hypogonadism due primarily to testicular cause (low testosterone, high FSH& LH, low inhibin-B)  .This  is often  characterized by deficiency in testosterone hormone production while in  case of secondary hypogonadism, defect lies at the level of hypothalamic-pituitary axis(Low FSH, low LH, high inhibin).
How Clomiphene acts in male subfertility where Leydig cells fails to synthesize adequate Testosterone? Ans; we know that a very large amount testosterone must be synthesized by Leydig cells which will diffuse  to supporting cells called  Sertoli  cells which will pass the freshly locally produced Testosterone to  primary spermatocytes and facilitate mitois of primary spermatocytesà followed by meiotic division . If Testosterone concentration synthesized by Leydig   cells is suboptimal then there will be poor division of  pri spermatocytes.   I this context remember that in case of oocytes mitotic Divion never occurs after birth but  in males mitotic division of gametes continues to occur .
Treating male hypogonadism by accelerating the  endogenous production of testosterone instead of exogenous hormonal preparation is the ideal choice. Thus, the ideal treatment is by blockade of E2 synthesis, secretion of more FSH and LH and up regulation of the testosterone secretion by testes


Investigations in a case of anovulation.
The following women are contraindications for CC:
1) WHO Type 1:-Low levels of FSH & E2,
2) Women who fail to respond to withdrawal bleeds are not the candidates for CC.




  

Can we avoid laproscopy before we initiate Medical management of Endometriosis associated pain ?? dical magemnt of endometrisis?


Can we avoid laparoscopy in women with Chronic pelvic pain with no demonstrable palpable/ visible / sonological cause for persistent pelvic pain?? Your opinion?  Can we offer her a trial of medical therapy based on clinical examination alone??

Ans:-  We must be aware that “Chronic pelvic pain-CPP” - frequently occurs secondary to nongynecologic conditions that must be considered in the evaluation of affected women. For women in whom endometriosis is the suspected cause of the pain, laparoscopic confirmation of the diagnosis is unnecessary, and a trial of medical therapy, . In fact one can use  second-line therapies such as danazol, GnRH agonists, and progestins, is justified provided that there are no other indications for surgery .
 Indications for surgery? If therte is  presence of a suspicious adnexal mass.
\Laparoscopy or opeb laparotomy?? Ans:-laparoscopic approaches seem to offer comparable clinical outcomes to those performed via laparotomy, but with reduced morbidity.
Q.6. what about adjuvant post operative medical therapy postoperative medical therapy??  Ans:-Yes. Its beter for prevention.So, the balance of evidence supports the use of adjuvant post operative medical therapy after conservative surgery for CPP. There is some evidence that adjuvant presacral neurectomy adds benefit for midline pain, but currently, there is inadequate evidence to support the use of uterosacral nerve ablation or uterine suspension. Hysterectomy alone has undocumented value in the surgical management of women with endometriosis-associated CPP.PMID: 12413979

Tuesday, 26 May 2020

How useful is continued lactation in prevention of pregancy??


. Breastfeeding as a method of Birth Control: Lactation Amenorrhoea Method (A Type of N F P- Natural Family Planning Method.)
Introduction
     This is the most common method of contraception in the first six months after childbirth. Scientists have recently designated this form of family planning as ‘Lactation Amenorrhoea Method’ or L.A.M. It is the use of breastfeeding as a temporary family planning method. LAM provides natural protection against pregnancy and encourages planning for initiation of another method at the proper time.
Who will get the Contraceptive Protection by breast feeding? Not all lactating women are going to be protected against pregnancy. Only following group of women are protected against pregnancy during breastfeeding period i.e. provided
a)                  Her baby gets at least 85% of his or her feedings as breast milk, and she breastfeeds her baby often, both day and night   AND
b)                  Her menstrual periods have not returned since childbirth , AND lastly,
c)                   Her baby is less than six months old.

All these three criteria should be fulfilled to achieve near 100% contraceptive effect of breastfeeding. If a women keeps breastfeeding very often, her protection from pregnancy may last even longer than stipulated six months and perhaps as long as nine to twelve months or beyond  after last childbirth. This is called extended use of LAM. Knowingly or unknowingly, rural women enjoy the benefit of this method of  extended L.A.M. as LAM continue to offer contraception to some even beyond six months. This is truer and often availed by Indian rural women. This is a type of natural family planning and costs nothing. Our nation therefore avoids several thousand unwanted births annually by adopting extended LAM method. In this context it may be pertinent to mention that a mother should ideally breastfeed up to two years along with weaning at six months followed by supplementary foods (partial breastfeeding).

Detailed criteria of LAM
As stated earlier to make breastfeeding as a successful method of natural contraception the woman concerned has to follow all the following criteria e.g.
1.                  She should breastfeed at least six times during day time and at least one preferably two feeds at night without supplementing water or any other drink. This is what is called exclusive breastfeeding. Author wonders how many urban women will take the trouble to put her baby to breast two or three times in night. LAM to be cent percent effective total feeding duration i.e. suckling time in twenty four hours should be ideally above eighty minutes or more.
2.                   As soon as menstruation resumes after childbirth she should commence some form of contraception because it is well known that contraceptive efficacy of LAM is markedly reduced as menstruation resumes after childbirth.
3.                  The contraceptive efficacy fades markedly six month after childbirth in spite of continued breastfeeding. Therefore, six month age of infant is a landmark for initiation of contraceptive even if menstruation do not resume.
Efficacy of LAM as contraceptive
 LAM method of contraception is about ninety eight effective in preventing conception in first six months postpartum provided the concerned woman remains amenorrhoeic (nonoccurrence of menstruation). How reliable is breast feeding? The failure rate of LAM is up to two pregnancies per 100 women in the first six months postpartum provided no supplementary food is added to baby during this period. This means strict adherence to the policy of exclusive breastfeeding. Nevertheless, two percent failure rate is not uncommon with other contraceptives too and no couple should raise their eyebrow on this minimal failure rate.

Advantages of adopting LAM as Contraceptive:
1.                  Effectively prevents pregnancy for at least first six months and this the period of coverage may be longer if a woman keeps breastfeeding often, day and night.
2.                  Encourages the mother to adopt standard breastfeeding patterns thus indirectly improves health of infant. The couple and relatives should remember that breast milk provides the healthiest food for the baby.
3.                  No direct cost for family planning.
4.                  No question of contraceptive related side effects.
5.                  No need to do anything at time of sexual intercourse. Coitally independent like Copper IUDs. Does not interrupt the pleasure of sex in the midway as is common in withdrawal method or condoms.
6.                  Protects the baby from life-threatening diarrhea and protects the baby from other infectious diseases such as measles and pneumonia (respiratory tract infections) by transmitting the mother’s immunities to the baby through breast milk. In Indian context breast milk provides a natural and highly effective panacea against fatal diarrhea of neonates and infants.

Disadvantages of LAM method of contraception:

1.                  Effectiveness after six months is uncertain Inspite of continued breast feeding.
2.                  The words ‘exclusive breastfeeding’ sounds simple but it requires considerable effort and dedication on the part the woman. Frequent breastfeeding, though ideal may be inconvenient or impractical for some women, especially working mothers.
3.                  Unlike condoms, there is no protection against sexually transmitted Infections (STIs) including HIV/AIDS. Thus if a woman is infected with HIV and if her partner does not use condom during sexual intercourse she may transmit the HIV through such unprotected sex. Therefore ideally partners of all HIV positive women should use barrier methods of contraception during all sexual intercourses though women can use female condom or newer cervical barrier devices (Leas Shield, Fem Cap) which will be equally effective in prevention of STI. The newer designs of female condom is claimed to be superior in STI prevention e.g. Reddy Female Condom, V-Armor Female Condom, Panty Condom. F-C female condom, Feminine condom (by Medtech Products). Breast milk, however can also can transmit HIV virus to neonate though such chance again is little. Such transmission of virus through breast milk is also applicable for Hepatitis B virus which is also secreted in milk. Most of the credit of newer male and Female condoms(Designer Condoms) goes to “CONRAD”-an organization dedicated to innovation and development of newer condoms including Spring laden Condoms, Inspiral Condoms, Contoured condoms, Sensidot Condoms ,Flared condoms,  Glans-covering condoms,  Oscillating condoms,  Spiral Condoms,  Glow-in-Dark condoms to name a few including invisible condoms(vaginal microbicides) for use of female partners. .

Limitation of breastfeeding as contraceptive:
     Though, breastfeeding is an important and effective means of child spacing, still some uncertainty exists about the extent to which a woman can rely on lactation induced suppression of ovulation for contraception. This is because feeding practice varies from women to women.
When compared to oral contraceptives or sterilization, breastfeeding may not be that effective form of contraception, due to following factors since a) Not all women ovulates as per norms and some  women may occasionally resume ovulation within six months of childbirth while still breastfeeding as per norms. It all depends on b) how frequently the baby is put to breast and above all the total duration of breastfeeding per twenty four hours.
 It is needless to mention that these two factors have great individual variations. What is more important, that there can be day to day variations due to maternal or infant illness or for social or religious reason? Thus if a woman fails to breastfeed as per norms for   couple of days then ovulation can ensure prematurely.
All these factors pose a problem in judging initiation of additional contraceptive in an individual woman. Therefore, there is a need of individualization in timing of initiation of contraceptives during breastfeeding period which is at times a difficult task on the part of doctor or HCP (Health Care Provider).
     As stated earlier during lactation amenorrhoea the probability of pregnancy for first six months is initially low i.e. 2%. But chance of pregnancy increases after six months even if the woman concerned remains amenorrhoeic (nonoccurrence of menstruation). All Breastfeeding women should remember that once she regains her menstrual pattern, contraceptive reliability induced by breastfeeding decreases rapidly and hence other means of contraception are always advisable. This applies particularly when the baby is being weaned and solid foods are gradually introduced. As stated, in rural India partial breastfeeding may continue for many months which offers some protection from pregnancy but not hundred percent.

Bellagio Consensus on L.A.M. of Contraception:
     In 1988 a group of reproductive scientists from all over the world met in Bellagio, Italy. They proposed that postpartum women could use lactation amenorrhoea method as a means of family planning. It is these experts who first unambiguously disclosed that women who are fully or nearly fully breastfeeding and amenorrhoeic are likely to experience a risk pregnancy at the rate of less than two percent in the first six months after childbirth. This consensus later came to be known as ‘Bellagio Consensus’. This method of natural contraception, very rightly was soon widely accepted in many countries. The principle of Bellagio consensus as a standard method of natural family planning was reaffirmed by another meeting at Bellagio in 1989 and this consensus was renamed as ‘Lactation Amenorrhoea Method (LAM)’ of contraception.
     Incidentally, it may be recalled that International consensus conference on Medical abortion i.e. nonsurgical method of abortion was also held at Bellagio city, Italy, 1-5th November 2004 under the auspices of World Health Organization, Rockefeller Foundation and a NGO (IPAS). Thus Bellagio city is dedicated to reproductive rights and reproductive freedom of woman!
     After Bellagio consensus an International guidelines on ‘Breastfeeding and LAM’ were framed in 1989 and these guidelines were widely circulated in different countries. These guidelines included all three previous standard criteria, all of which must be fulfilled to ensure adequate protection from an unplanned pregnancy i.e. a) amenorrhoea, b) full or nearly full breastfeeding, c) first six months postpartum. The newly issued guidelines however included one additional warning for lactating women. The warning is that if any women who no longer meet all these three criteria, or no longer wish to use LAM, should immediately initiate use of additional family planning method if she intends to avoid pregnancy. It means partial breastfeeding does not offer cent percent protection from pregnancy. The guideline however had another clear message. That is it is the suckling stimulus that results both amenorrhoea and associated protection from pregnancy due to an anovulation (no release of eggs). Hence, adding supplements to the infant’s diet or decreasing the duration of breastfeeding below sixty minutes per twenty four hours and therefore  decreasing total suckling period may hasten the return of ovulation and shorten the efficacy of LAM.
Bellagio consensus also encompass and also  stress on the relevance  on  extended use of LAM?
As an Indian we would be interested to know the effect of extended breastfeeding on contraception i.e. if breastfeeding is continued beyond six months. Many women in rural India breastfeed up to four or five years. What opinion the said experts expressed on breastfeeding-induced natural contraception in such cases? Are they as immune to pregnancy as is enjoyed in first six months? Certainly not. Let us now see what experts say on this issue which is so relevant in Indian context.
Experts opine that it may be possible to extended  LAM beyond six months and there is nothing wrong in this age old practice. But so far as contraceptive effect is concerned their argument was that infants older than six months definitely need some supplemental feeding to maintain their health and development. Naturally, supplementation with other foods decreases breastfeeding frequency considerably. This by reducing suckling duration can result in release of eggs from ovaries. The experts also warned that in such cases ovulation and mistimed pregnancy can follow even if she remains amenorrhoeic. As such, women who continue to breastfeed beyond six months despite supplementation. In fact that is the usual scenario in rural India) the rate of pregnancy during ‘lactation amenorrhoea’ will be higher than that of first six months postpartum. Pregnancy rate however, remains low, than those women who do not breastfed at all. This is called ‘extended use of LAM’.
     Many studies on LAM were conducted since Bellagio consensus. Experts again gathered at Bellagio on 4th Dec, 1995 and they collectively reviewed all the study reports which were available from different countries. The committee concluded that the Bellagio consensus of 1989 was worthy and appropriate including ‘extended use of LAM.’ Sporadic studies conducted thereafter (1996-2008) to assess the validity of Bellagio consensus have reaffirmed that women who are fully or nearly fully breastfeeding are at very low risk of becoming pregnant in the first six months postpartum or as long as they remain amenorrhoeic.
How can we motivate Indian mothers to accept scientific breastfeeding practices?
There is urgent need to educate all pregnant women (would -be -mothers) about standard breastfeeding practices. Family members and community leaders should also be communicated about benefits of exclusive breastfeeding and other healthy breastfeeding practices. Doctors and health care providers too need updating of their counseling skills on breastfeeding by attending workshops and seminars on this issue. Their noble duty is to part all these scientific knowledge i.e. ‘Dos’ and ‘NOT to dos’ to would be mothers during prenatal visits and also during discharge from hospital or nursing home after childbirth.
a)        Who is responsible for ‘wrong breastfeeding practices’ ? Readers will be shocked to know the results of one Indian survey. This recent study disclosed that of the mothers who decided for early formula feeding 46% were motivated by the suggestions received from family members and neighbors and in 43% such women the decision to start a formula feed was influenced by the doctors and health workers! What an unfortunate scenario! In rest 11% women who started formula feed too early were influenced by different media and advertisements. Now radio talks and TV talks are on to motivate mothers and in- laws.
b)       We can do better: Tips to promote breastfeeding: Breastfeeding and family planning are mutually reinforcing components of any health policy. Many of us understand that early discontinuation of breastfeeding presents considerable health hazards to infant. But we seldom understand that acceptance of standard breastfeeding practice not only benefits the concerned infant but also increase the birth interval by inducing lactation amenorrhoea. Lactation anovulation associated with amenorrhoea resulting from exclusive breastfeeding represents an important child-spacing mechanism in many third world countries. This is because frequent stimulation of the nipple during breastfeeding produce prolactin hormone which in turn reduces some hormones called pituitary ( a gland located in  brain )(pituitary gonadotrophins). It is this prolactin hormone which causes inhibition of menstruation of egg release.
Never be happy with the status Quo: The contribution of lactation amenorrhoea to birth spacing should be categorically disseminated to mothers especially during the prenatal visits. Basic information on ideal breastfeeding practice should also be c6tedcommiased to family members, in laws, and opinion leaders in the community.
The following globally accepted practice should repeatedly be communicated while the mother is still in hospital or nursing home these are a) exclusively breastfeeding for first six months, with frequent suckling on demand, both day and night. b) Continuation of breastfeeding even after supplemental foods has been introduced after 6 months. C) The most appropriate time for introducing other family planning methods should be established, for each individual based mainly on breastfeeding patterns and trends, and obviously on the duration of lactation amenorrhoea. The couple should also be made aware of the available fertility regulating methods, for lactating women. The couple should preferably use nonhormonal methods of contraception e.g. IUD (Intra-uterine devices) or condom. In the authors opinion these two are ideal contraceptives from four to six months postpartum.
But those breastfeeding women who desire hormonal contraceptive protection they can choose progesterone only hormonal contraceptives e.g. minipill or Inj. Progesterone i.e. quarterly shots. This hormonal method also has a track record good efficacy and safety. If none of these four methods are selected the combined oral contraceptives may be started only after six months of childbirth as it adversely affects quality of breast milk (WHO category 2 risk so long baby is breastfeeding).
However to initiate and promote breastfeeding important of personal support is very relevant. Personal contact and support really helps breastfeeding to succeed. This may be from health workers, counselors, family members, or from other breastfeeding mothers in the community. Radio broadcasts, newspaper articles and lectures can increase people’s knowledge, but they may not change what mothers do. Person-to-person help is necessary to convince mothers to put the ideas into practice.

Support for a breastfeeding mother means a kind person who can:
-      See her often, help with practical tasks, and avoid saying anything critical.
-      Reassure her that she cans breastfeed and that her milk is perfect and sufficient.
-      Praise her for what she is doing right.
-      Explain what is normal.
-      Advise her if she does not know what to do.
-      Help her if she was a problem.
-      Encourage her to persist.
What points need to categorically discuss during antenatal period.
1.        Her breast milk is always the best food for her baby. The quality of the milk will always be good whatever her diet.
2.        The size and shape of the breasts does not matter. Small breasts and large breast both produce milk in sufficient quantity, and a baby can suckle from any of them.
3.        Breastfeeding does not spoil her figure. It should help her to lose weight after the baby is born. Having a baby always alters the breasts – whether or not the mother breastfeeds. Most changes that are seen in older women are partly due to age. If she wears a well fitting brassiere or other support while she breastfeeds, her breasts will have a good shape.
4.        Bottle feeding is dangerous. If family and friends urge the use of a bottle, explain that this practice is no longer recommended because it causes much illness. Baby –Friendly Hospitals have come up since early 1990s.
5.        Let the baby suckle soon after delivery – within an hour if he is willing. She should keep the baby with her and let him suckle whenever he wants to from the first day. This helps the mother’s milk to come in.
6.        She can make one or two of her dresses open at the front so that the baby can reach the breast easily. This helps her to breastfeed modestly, without exposing the breasts.
7.        All mothers feel more emotional and sensitive than usual for a few weeks after delivery. It helps to know that these feelings are normal and that they will pass. (Adopted from: “Helping mothers to breastfeed” by felicity savage king, published by ACASH publication, Post Box No. 2948, Mumbai 400 002, India. Author pays a big salute to such a publishing authority. This is like a patriotic duty.




Take home message:
‘Lactation Amenorhoea    Method’ of natural contraception is prevention of conception in first six months of childbirth During the past few years, there has been a rapid increase in scientific knowledge about the relationship of ‘breastfeeding and suckling practices’ to ‘reproductive function and natural infecundity’ during breastfeeding. Much have been known about social and adverse health consequences of unregulated fertility not only on mothers, but also on increasing population, the family and the community.  But to achieve contraceptive effect of breastfeeding adequate time should be spent on breastfeeding (nursing should be more than six times per day including at least one feed at night) and there should be no resumption of menstrual period following childbirth.  If a) breastfeeding is less than six times per day or b) less than 80 minutes per day or c) menstruation has resumed after childbirth or baby is already six months old then efficacy of this method of contraception considerably lessens.
Now-a-days unfortunately a busy house wife often comprises with duration and frequency of breastfeeding due to her occupation and or social commitments. Publicity regarding benefits of breastfeeding is inadequate. Unfortunately there is minimal response from community on this aspect. However, if unscientific breastfeeding practice cannot be rectified then little can be done to improve health of baby. But natural contraceptive benefit offered by healthy breastfeeding for first six months (L.A.M method of contraception) can be covered by alternative contraceptive. Hence there is a crying need for early initiation of contraceptive use which may be as early as three months or even two months postpartum!
 As civilization progresses the duration of breastfeeding is decreasing and the concept of ‘lactation amenorrhoea method of fertility control’ is fading. This is unfortunate. Globalization is engulfing our golden old cultures in every sphere of life. A day may come in twenty second century when there will be no chapter on LAM in a book of postpartum contraception. Hope this won’t occur!

A Lactating woman can use following algorithm for ready reference:
Can a Woman Use LAM?
 Doctor/Counselor should ask the mother, or advise her to ask herself, these 3 questions:

1.                  Have your menstrual periods returned after childbirth?

If YES

The mother’s chance of pregnancy is increased. For continued protection, advise her to begin using a complementary family planning method and simultaneously to continue breastfeeding for the child’s health.

2.                  Are you regularly giving the baby much other food besides breast milk or allowing long periods without breastfeeding, either day or nighttime?

If YES

3.                  Is your baby more than 6 months old?

If YES

If the answer to ALL of these question is NO       But, when the answer to any ONE of
                                            These questions becomes YES
 


She can us LAM. Only breastfeeding will prevent fresh pregnancy. There is no need to commence any other contraceptive. But there is only a 1% to 2% chance of pregnancy at this time.( Source: W H O).

Web Sites:
a.                   Association of Breastfeeding Mothers (http://abm.me.uk/website/index.htm);
b.                  Breastfeeding Network (www.breastfedingnetwork.org.uk/);
c.                    Best Beginnings (www.bestbeginnings.info/) – Video clips of breastfeeding positioning and attachment
d.                  Dipex (www.dipex.org/breastfeeding) – Video clips of women talking about their breastfeeding experiences and web links to other information resources.
e.                   Breastfeeding your baby (www.eatwell.gov.uk/agesandstages/baby/breastfeed/) – Advice on what to eat when breast feeding.
f.  UNICEF (www. Childinfo.org/eddb/brfeed/index.htm) – Breastfeeding and complementary feeding Country.
g.                   UNICEF UK baby friendly initiative (www.babyfriendly.org.uk/) – Supports health services to provide high quality care. Information about training and the latest research updates.
h.                  Drugs in Lactation Advisory Service – www.ukmicentral.nhs.uk/drugpreg/guide.htm
Breastfeeding Network Drug line (a registered charity) –

i.   rk.org.uk

Followings are uncorrected.  A.4
A Text Book on Breast Feeding and Child Spacing
(    Vol – I     )

AUTHOR
                Prof. S.K. Pal
M.B.B.S., D.G.O., M.S. (Gynaecology), F.I.C.O.G., F.I.C.S. (U.S.A.), F.A.C.S. (U.S.A.)
Prof. and Head, Department of Gynaecology, Obstetrics & Family Planning
Residence: GD-207, Salt Lake, Kolkata – 700 106, Phone:     +91-33-23376954  (Mobile: +91-9333315050)

Information about the Book:    This book describes the details of healthy breastfeeding practices which are recommended by Internationally Recognized Academic Bodies. Unfortunately many women are unaware about the details of normal breastfeeding practice. As such quite often the baby is put to breast 24-48 hours after their birth. Colostrums (Yellow Milk) the first milk which is secreted soon after birth is often denied to new born which is a very bad practice. Because this colostrum contain many protective factors which prevent diarrhoea and bronchitis of infants. It is a common observation that before putting to breast for the first time after birth some other liquid food is offered e.g. water, honey or sugar water (pre-lacteal feed). These interfere with subsequent milk production in the mother’s breast.
Many a mother do not know what is meant by Exclusive Breastfeeding for first six month after childbirth. The position of the mother and the position of the infant during the breastfeeding process are seldom discussed in the prenatal or postnatal visits; as a result often a part of nipple only is introduced in the mouth of infant. Ideally entire nipple, areola and a part of breast should be put to the mouth of the infant so that he / she can suck the breast adequately with full force and can draw his / her food in a natural way. This is often a common cause of inadequate milk production in the breast. This treatise also discusses the importance of breast milk in maintenance of health of infant. It also highlights how to breastfeed a sick child and how a working mother can help her baby to get own breast milk in spite of her busy office work. This is an important book for all women who are going to give birth soon or who are already breastfeeding their child. A Chapter on human breast milk banking has been included.


Initiation of Birth Control Measures after Childbirth and Choice of Contraceptives during breastfeeding period

(Postpartum return of ‘menstruation’, ‘ovulation’ and ‘fertility’ – possibility of unintended pregnancy in lactation period – list of available contraceptives which may be safely used during postpartum period)
I.            Defining the Problem: When fertility returns in lactation period? The answer not exactly known:
     The exact time of the fertility returns in postpartum period eludes the awareness of many women. The proper timing of initiation their understanding and appreciation. Scientists too are equally in dilemma so far as timing of initiation of contraceptives after childbirth is therefore not within the orbit of their understanding and appreciation. Scientist too are equally in dilemma so far as timing of initiation of contraceptives after childbirth is concerned. This is simply because there is no set chronology of events like ‘return of menstruation’, ‘resumption of sexual activity’ and ‘restoration of ovulation’. All these variations are primarily due to changes noticed in breast feeding practice and thus the possibility of further pregnancy. Return of ‘fertility’, though primarily depend upon frequency and duration of breastfeeding but there is gross individual and racial variation. It is all these variations which have prompted the author to write a special chapter on this issue i.e. timing of initiation of contraceptives in lactation period.

In spite of innumerable member of cross Country population breast studies the speculation on return of ovulation and thus possibility of face pregnancy in postpartum period still remains a matter of speculation  :

We know that pregnancy to occur there must be availability of egg released from ovary a process termed as ‘ovulation’. Sperms also must be available in female genital tract by the process of sexual intercourse. The act of intercourse however can be easily accessed by the couple themselves but the process o ovulation and thus presence or absence of ovum can’t be assessed neither by the wife nor by the husband. Because the process of ovulation do not cause any noticeable symptom or distress so that no woman can say with certainty when she has ovulated and thus in need of contraception unlike ‘menstruation’, ‘breast feeding’ and ‘sexual act’ unfortunately the process of ovulation remain asymptomatic.
     Due to lack of this scientific knowledge some women are unnecessarily initiating contraceptive too early. There is still another group who are eager to use contraceptive but they do so quite let in lactation period. This chapter critically analyze the different factors that influence the return of ‘fertility’ in postpartum period. This chapter also highlights the time of initiation of contraceptives at an appropriate time and taste of contraceptives which can be safely used in lactation period. The magnitude and impact of ‘unintended pregnancy in Lactational period have also been discussed briefly.

II.       Where we were? What the couple used to do earlier in initiation of contraceptive?

At the present time of writing a conclusions couple has three choices about timing the initiation of contraceptive lactation period. Firstly, the couple consider initiation of contraceptive whenever they resume sexual activity after childbirth. Logically it is a good practice but, quite often the sexual activity resume after childbirth time when many women are naturally in fecund due to lack of resumption of ovulation. Thus if initiation of sex is considered as the index of commencing contraceptive there will be always a chance of initiation contraceptives too early which is possibly a burden to the couple. As stated earlier, unlike menstruation and ‘sexual act’ the act of ovulation cannot be perceived by the woman. Thus a woman remains unaware about resumption of ovulation in postpartum period.

There is a second group of women who start using contraceptives only when they discontinued breastfeeding : But this philosophy is wrong and unscientific because many woman do omelet after six month of childbirth insatiate of continued breastfeeding. There is a third group of couple who would like to commence contraceptive whenever menstruation resumes in postpartum period. This philosophy apparently sounds well but a adoption of this method of initiating contraceptive is also unscientific such policy may give rise to unintended pregnancies because in many breastfeeding women ovulation precedes visible event of menstruation. Thus scientifically speaking restoration of menstruation also cannot be used as an index of initiation of contraception.

III.   What woman expects from Science ?
     Most couple would like to start contraceptive when ovulating resumes and dislike using contraceptive unnecessarily before resorption of ovulation. There is a real taste of science in this belief. Thus return of ovulation as an index of starting contraception though scientifically correct but the process of ovulation can’t be gauged at the present state of knowledge.
     No cheap method for detection of resumption ovulation is available. It would have been easier on the part of couple and scientists too if there have been a easy readymade low cost but predictable monitoring method of assessing maturation and release of eggs. Unfortunately whatever home monitoring tests for ovulation exist that are too costly for planning contraceptive use. Till date the use of these tests are limited to infertility treatment only.
What PREVALENCE     AND  ILL EFFECTS    OF   ‘ POVERTY ‘   AND  THEREFORE   ‘HUNGER   BURDEN ‘   & ‘MALNUTRITION’   OF   OUR   RURAL   PEOPLE
IV.  On which factors the present day woman should depend on imitation of Contraceptive?
Thus till date couple as well as scientists are arbitrarily guided by three indices. These are a) nature and frequently of breastfeeding b) the event of return of menstruation. And c) resumption of sexual activity. Return of ovulation though the most decisive index of commencing contraceptive cannot be used by couple as index of initiation of contraception population at the present state of knowledge.
Additionally in office seating  i.e. when a couple come to clinic for advice in postpartum period the contraceptive specialists usually require on nature of breastfeeding practice and return of menstruation as the two indices for planning on contraceptive use in postpartum period and the HCP thus tries to correlate the possibility of return of ovulation with these two events. This is just a grass of probe ability of becoming pregnancy. Couple too have relied either on return of menstruation or initiation of sexual activity as indices of initiation of contraceptive and of they at all rely on nature of breastfeeding they consider wearing as the index.


Contraceptives which are licensed abroad but not available in India (Newer birth control options):
1)                  Extra-pleasure condoms, Oscillating condoms, Glow-in-dark condoms, Extra strenth-Cond  ms, Extra thin-Condoms , Baggy Design Condoms etc.
2)                  Synthetic Male Condoms
3)                  Newer Oral Contraceptives, (Minesse, Seasonable).
4)                  Monthly Injectables (for women e.g. Lunella)
5)                  Newer quarterly shots (Sub cut route)
6)                  Contraceptive Implants (Implanon)
7)                  Transdermal patch (Ortho Vera patch), application weekly.
8)                  Vaginal rings (NUVARING)
9)                  Frameless IUD & other newer IUD’s
10)          Newer contraceptive sponge e.g. (conceptual & Protectaid sponge)
11)          Electronic Fertility Monitor (persona)
12)          Reddy Female Condom
13)          New cortical barriers (Fem Cap/Lea’s shield)
This description does not cover all new contraceptive that have been released abroad.


V.       Summary of the present problem : Where we are now?
Principally there are four factors which control return of ovulation and the restoration of fertility and each of the factors mentioned below deserve detailed discussion. The factors are a> Frequency and duration of ‘breastfeeding’, b> Restoration of ovulation, c> Resumption of ‘menstruation’ after childbirth and above all, d> initiation of ‘sexual intercourse’. Let us now analyse the role of each of these four factors and each of these four factors incluence return of fecludity independently it is worth remembaring that though breastfeeding, take a lead role but the process of restoration of ovulation resumption of mensturation are usually but not always interrelated. We shall see in the following pages that always choice by benefit for and resumption of menstruation. The process of ‘ovulation’ and ‘resumption of menstruation’ are not always controlled by breastfeeding. Giving identical time in breasefeeding two woman will outlet in different times. Thus it is this natural ovulation which cause much concerned to couple to fix up a time for initiation of contraceptives.

a)        Frequency and duration of breast feeding per 24 hours
b)       Resumption of menstruation
c)         Initiation of sexual activity
d)       Return of ovulation (arbitary)
All these four factors have been discussed at length in the following pages. The relevance of al these four factors have been explained in details thus enabling couple to initiate contraceptive at a reasonably appropriate time. Admuttedly, till date there is as yet no set guideline about commencement of contraceptive in postpartum period due to inaccuracies fallancies of all these four indices to foretell about the probability of pregnancy.

A.                 Nature of breastfeeding and return of postpatum fecundity :
So far as duration of postpartum insusceptibility to pregnancy is concerned not only the total months for which the infant is breastfed is mportant but frequency and total duration of breast-feeding per twenty four hours are also important. Presumably, many educated couple are aware that frequent breastfeeding practice prevents conception by inhibiting release of eggs from ovaries but only few of them are aware that adoption of this method of natural contraception has been recently renamed as ‘Lactational Amenorrhoea Method (LAM)’ PARA. In LAM there are three factors to be considered. Unfortunately for lack of proper publicity few Indian couple have an clear idea on thest three essential criteria to make LAM method of natural contraception successful. These three criteria are a) exclusive breastfeeding including on or two feeds at night b) Persistence of postpartum ammenorrhoea (nonoccurence of menstruaton) and this contraceptive efficacy of LAM last only for first-six months after childbirth. Contraceptive effieacy fades after six months inspite of continued breastfeeding.
The importance of breastfeeding in preventing contraception can be easily ganzed by following observation. Sevently-five percent of non-lactating Indian women conceive within six to nine months of delivery if effective contraception is not practised as against only 7-10 percent of those who breastfeed as per international norms.

B.                 Partial breastfeeding and early return of fertility :
How vulnerable are women who breastfeed infrequently or for only short duration, ‘Menstruation’, ‘Ovulation’ and therefore ‘fertility’ return sooner than expected in such women and unintended pregnancy can occur quite early say within three or four months after childbirth inspite of continued partial breastfeeding.
Owing to lack of this particular scientific information many women fall prey to unintended pregnancy in lactation period. They are under the false impression that they are immune to pregnancy because of so called breastfeeding. In fact, partical breastfeeding confers little protection against pregnancy as suckling of breasts in infrequent and hence ovulation is not inhibited appropiately. The incidence of ‘escape ovulation’ during partial breastfeeding though not universal but is a distinct possibility.

C.                  What is then partial breastfeeding?
By partial breastfeeding we mean infreqent and short-lived breastfeding that needs to be supported and supplemented by edible extra-milk or non-milk products before six months of age. This practice of providing extra-feeding is the total negation of science. If partial breastfeeding practice is adopted then twenty percent of such women will menstruate as early as two months after childbirth! I wonder, how many partially breastfeeding Indian mothers are aware of this fact before they embark on unprotected intercourse.
In fact, they simply do not know that they are susceptible to pregnancy even as early as two months after childbirth! I am also convinced that majority of such Indian women do not use any contraceptive whats over as this early postpartum phase. It is thus importantto fully breastfeed for first six months to avail and enjoy contraceptive efficacy of breastfeeding. Some scientist however claim that ‘Lactation’ and ‘Ovulation’ are antagonistic but it has now been proved that this principle does not hold good after six months postpartum. What happens is that during lactation prolactin hormone in maternal blood (milk secreting hormone) is high and this hormone suppresses the action of gonadotrophins (hormone responsible for release of eggs from ovaries). To simplify, ovaries of breastfeeding women are to some extent refractory to the actions of gonadotrophin hormones responsible for release of eggs. So elease of eggs from ovaries remain suspended at least for first six months provided no supplementary feed is allowed and menstruation has not resumed. This is exactily what has been called earlier, Lactational Amenorrhoea Method of contraception (LAM).

D.                Return of Ovulation in postpartum period :
Postpartum Return of ovulation release of eggs varies from woman to woman and as stated earlier, the timing of first ovulation in postpartum period primarly depend on frequency of breastfeeding and duration of breastfeeding. In nonlactating mothers ‘ovulation’ can rare occationally resume as early as twently one day after childbirth. Many nonlactating women do ovulate by sixty days postpartum.
By contrast who breastfeed as per international norm in them resumption of ovulation frequently precede the onset of menstruation. So the general belief of commencing contraceptive after resumption of menstrual period does not hold good. Unfortunately, many Indian women still believe that unless menstruation returns till then she is protected from pregnancy. This false sense of security is a common cause of unintended pregnancy in postpartum period.

E.                  Return of menstruation and return of fertility :
S. long we have discussed about role of breastfeeding in preventing pregnancy. We now focus on the spatial relation of return of menstruation in postpartum period and possibility of fresh pregnancy.
Postpartum amenorrhoea i.e. nonoccurrence of menstruation is the interval between the birth of a child and resumption of menstruation. It is the period following childbirth during which a woman becomes temporarily and involuntarily in fecund.
Admittedly the duration and frequency of breastfeeding primarily govern the length of postpartum amenorrhoea but there are other hitherto unknown factors as well. As breastfeeding practice varies in different parts of India so also the duration of postpartum amenorrhoea (nonoccurrence of menstruation). However the usual trend of amenorrhoea amongst India women is discussed below.

Postpartum initiation of sexual intercourse :
As this chapter is dedicated to fix up the time of initiation contraceptives in postpartum period it will be pertinent to highlight some aspects of human sexual behavior in postpartum period.
Postpartum coital behavior varies greatly in different parts of globe. Initiation of sexual activity depends on factors like socio cultural taboo, health of the partners, nature of delivery (natural or caesarean) whether the women stays at her father’s residence and obviously the educational status of the couple. By and large most couple start enjoying sex by three months after childbirth. A woman need not consider contraceptives if she is not exposed to the risk of pregnancy either because she is amenorrhoeic (true for first six months of after childbirth) or because she is abstaining from sexual intercourse.
A recent European study revealed that after a normal birth ninety-four percent abstain from sex in first month and as postpartum duration proceeds the rate of abstinence falls. As many as twenty percent of European women abstain from sexual intercourse eight month after birth and only as twelve percent retain from sex even twelve months after a birth! By contrast, a U.S. study, conducted in 1998 revealed that two thirds of new mothers report having resuming sexual activity by fourth month. Unfortunately, in the same study was also observed that fifteen percent of lactating women with last childbirth beyond six month report being sexually active but not using any contraceptive method and thus are at risk of unintended pregnancy. Due to lack of contraceptive knowledge they are simply unaware about the possibility of unintended pregnancy.
What about India? The proportion of mothers abstaining from sexual intercourse in the first month after a birth is nearly the same as the proportion amenorrhoeic (94 percent and 96 percent, respectively), but the proportion abstaining falls far more quickly with the passage of time since birth than does the proportion who are amenorrhoeic. Only one-quarter of mothers are still abstaining from sexual intercourse four months after a birth, and by six months, 85 percent of India women have resumed sexual relations (source : NFHS – 3).

What exactly than the time of postpartum initiation of Contraceptive :
Care should be exercised in individualizing such timeframe one should remember that sperm retain fertilizing capacity in the female genital tract five days after intercourse. Thus, it would had been appropriate if women could have assessed first postpartum ovulation process 3-5 days prior to the occurrence of ovulation. So that appropriate contraceptive method may be initiated prior to first ovulation. Unfortunately till date there is no such subjective symptom or Laboratory test exist which can detect ovulation 5 days prior to ovulation. Thus individualizing of initiation of contraceptive and possibly to some extent unscientific.
The degree of lactation induced inhibition of ovulation is difficult to assess from history and only a grass is possible. For instance, if frequent and prolonged breastfeeding is going on then early use of contraceptives may constitute and unnecessary double protection i.e. L.A.M. along with some other contraceptive what should be then, the take home message?
The international guideline is that a) for fully breastfed women (not giving any artificial milk, fruit juice honey etc.). Who has not yet started menstruation contraception should be commenced after six months of delivery. There is only two percent chance of conception during the last two months i.e. fifth and six month of postpartum period. One can use some contraceptive in those two months if one intends to avoid the said 2% risk though that is not the usual recommended protocol. B) Nonlactating women on the other hand and who partially breastfed they should definitely start contraceptive by two and four months after childbirth respectively unless the start menstruating earlier. C) After an abortion (spontaneous a induced) one should start using contraception after two weeks and not later. Before this timeframe for all practical purpose pregnancy is very unlikely though not impossible.
One may ask why not to initiate contraceptive from the very first sexual act in postpartum period? There is no harm if one opts using a contraceptive from the very first coital act after childbirth. But one has to consider that no contraceptive is 100% effective. If one accepts this philosophy of occasional ‘contraceptive accidents’, which is not uncommon, then above mentioned guideline is possibly more acceptable to couple rather than very early initiation of contraceptive.

Contraceptive Options after childbirth :
We have discussed about the timing of introduction of contraceptives in detail but attention must also be given to the type of contraceptive methods that are safe in this special period. Whatever contraceptive is chosen one has to remember that baby is breastfeeding and many drugs including systemic contraceptive are excreted in breast milk. Thus early initiation of systemic contraceptive (Tablet/Injection) should be better avoided unless they have proven safety profile for infant. The usual choices for first six months are male barrier methods (condom), progesterone-only-pill, intrauterine contraceptive devices three monthly progesterone injections and sub dermal implants (not available in India) on emergency situation one can resort to morning after pills e.g. postcoital pills.
We are whose that all hormonal contraceptives and IVD are very effective contraceptive but combined oral contraceptives reduce the milk secreting hormone prolactin and thus volume of milk may be reduced considerably. Therefore combined oral contraceptives which interfere with lactation process is not recommended at least for first six months postpartum. If hormonal contraceptives are used at all only progesterone containing methods should be used which do not reduce milk flow. These are either minipill (P) and three monthly injections (P).
Female barrier methods too may not be that effective due to laxity of genital tract Vaginal topical contraceptives like (sponge, pessaries and foam tablets (spermicides) are not very effective one. Couple often do not rush into permanent sterilization (vasectomy for male or tubectomy for female) in postpartum period unless family size is complete and a proper counseling is done in antenatal period. Many a couple repent after undergoing permanent sterilization. Where decision has been taken in a hurry and sometime they course health care provides for not allowing sufficient time to think over the issue of permanent sterilization (Tubectomy).

List of Contraceptives in postpartum period :
A.       Natural Methods :
a)                  Coitus interrupts (P)
b)                 Lactational Amenorrhoea Method (P)
c)                   Safe Period Method (P)
B.       Barrier Methods :
a)                  Male Condom (P)
b)                 Female Condom (P)
c)                   Spermicides (P)
C.        Hormonal Contraception (Progesterone only) :
a)                  Progesterone only pill (P)
b)                 Quarterly Injection (P)
c)                   Sub dermal Implant (P)
D.      Intrauterine Device :
a)                  Copper containing IUD (P)
b)                 Progesterone hormone containing IUS (P-4)
c)                   Newer IUDs (P-4)
E.        Emergency Contraceptives :
F.         Permanent Method :
a)                  Vasectomy (P)
b)                 Tubectomy (P)
List of Contraceptives and timing of initiation of Contraceptives after childbirth or abortion.
Nature of Family Planning Method
How early
one can adopt family planning measure
Non Breastfeeding
Breastfeeding
After Abortion
1)                  Lactational amenorrhoea
Not applicable
Immediately
Not applicable following first trimester abortion IUD may be applied immediately
2)                  Copper IUD
Within 48 hours, otherwise delay 4 weeks (WHO Category-2)
3)                  Male Condom
No
Restriction

4)                  POP
Immediately
Delay 6 Weeks
One can use these methods within seven days of abortion
5)                  Progestin only injectables
Immediately
Delay 6 Weeks
6)                  Implants
Immediately
Delay 6 Weeks
7)                  Combined Inj. COC, weekly contraceptive patch contraceptive vaginal rings
Commence 3 Weeks after childbirth
May be used after six months (but better to avoid so long baby is breast following (Category-2 risk)
COC may be commenced on the following day of abortion
8)                  LNG IUS
Delay 4 Weeks
Delay 4 Weeks

9)                  Spermicides
Immediately


Following second trimester abortion (gestational period 14-20 Weeks) one can be fitted with copper bearing IUD or LNG IUS (Mirena IUD) but expulsion rate of the device will be greater compared to first trimester abortion. These is no difference in safety or expulsion rate after insertion of LNG IUS compared to Cu-IUD.



Return of fertility after abortion :
Any conscientious couple will like to know probable duration between abortion and return of ovulation so that they can use contraceptive at appropriate time. Following an abortion, (Spontaneous or induced) a woman generally menstruates within four to six weeks. Contrary to term childbirth, the first period is often ovular in at least 75-85 percent of cases. As a matter of fact ovulation has been documented as early as eighteen days after spontaneous abortion. However, the mean time of commencement of ovulation post abortion period is 22-33 days. Hence, the chance of inadvertent pregnancy is much common after an abortion than after term childbirth. The golden rule, therefore, will be to initiate contraceptive two weeks after abortion. It is a herculean task on the part of doctors to counsel and communicate this message of timely initiation of contraception to 10 million mothers who undergo induced abortion annually in India as most of these women are non users of contraceptives. Paramedical staff, NGO officials and media can help to spread this message of reproductive health to such women Who may fall into prey of another pregnancy after induced abortion.

Relevance of Contraceptives what will happen if a couple do not use contraceptive?
     We were so long talking on initiation of contraceptives in postpartum period. Let us view the problem in a reverse way. What are the benefits of timely use of contraceptives? We know that the very purpose of using contraceptive is to avoid unintended pregnancies and non use can lead to mistimed pregnancy during lactation period. As conceivable most women proceed for induced abortion if they unfortunately conceive during breastfeeding period and in India many such abortion procedures are being carried by nonmedical persons (backstreet abortions). Interested readers may now enquire what is the global incidence of induced abortion? We are aware of the fact that globally about 210 million pregnancies do occur annually. We also know that not all pregnancies go to term. About fifteen Percent to twenty five percent of all human pregnancies end in abortion before three months of gestation. This unfortunate though ale bait natural process is commonly called miscarriage and no cause can usually be ascertained for this mishap. So far as induced abortion is considered one will be surprised to know that globally about 20 million pregnancies are voluntarily terminated each year! It is also estimated that 68,000 young women embrace death annually out of backstreet abortion. Conceivably many such unwanted i.e. mistimed pregnancies do happen in Lactational period and hence the relevance of commencing contraceptives in postpartum period at most appropriate time. The whole idea is to avoid untimely pregnancies and miseries of induced abortion.
     Induced Abortion Rate in India – ‘Difference between ‘Recorded figures’ and ‘Estimated figures’. It is also estimated that about 10-15 million spontaneous miscarriage do occur with great distress to the women concerned and grief to family members. In India there is 28 million pregnancies  per year with annual birth rate of 25 million and massages. But A large number of abortions are intentionally carried out in India even today for nonuse of contraceptives. There are many causes for nonuse of contraceptives. The abortion rate in India is 40-7- abortions per 1000 women of reproductive age which comes to an abortion ratio of 260-450 per 1000 live births! It is difficult to collect and definite figure on total annual induced abortion in any country but the estimated figure is only 1-2 million per year. There is about 12,000-20,000 maternal deaths per year due to such clandestine abortions in India. As a matter of fact 33-50 % of Indian women undergo at least one induced abortion in their lifetime! This is simply due to nonuse of contraceptives. Most of these abortion are carried out when the youngest child is below two years of age i.e. in lactation period.
     The death rate of such induced abortions if carried out in unsafe surroundings is about 50-200 per 1,00,000 such procedures which amounts to one maternal death in India in every 50 minutes due to unsafe abortion! All these figure points to relevance of contraceptives use in lactation period.
We have so long discussed about magnitude and ill effects of abortions in India. But what is the global situation? Unless we realize the magnitude of unsafe abortions we will not be able to assess the relevance or importance of contraceptive use in appropriate time nether the Indian couple will be able to realize why World Health Organization has declared contraceptives as essential drugs.

Scrutiny of National Unintended Pregnancy Rate in India Reveal that many Indian couple do not use contraceptives.
     The ‘unintended pregnancy rate’ varies in different countries. It depends not only on format education but also on contraceptive availability and contraceptive awareness of the couple of that country. For instance in India twenty one percent of all pregnancies that resulted in live births during the period 1997-98 and also in 2005-06 were unplanned i.e. unwanted at the time the women became pregnant. Ten percent women wanted later (mistimed pregnancy) and eleven percent women did not want all (source: National Family Health Survey-3, p.108). These statistics however refers to only those ‘untimely’ and ‘never wanted’ pregnancies which ended in live births. These statistics however do not include large number of unwanted pregnancies which ended in spontaneous or induced abortions or stillbirths taken together at is estimated that 50-60 % of pregnancy are either mistimed or unwanted! All these statistics point out that even today millions of such unwanted or mistimed pregnancies continue to occur in our country. It is needless to mention that majority of these mistimed pregnancies do occur during breastfeeding period and admittedly these mishaps occur due to lack of back knowledge of contraceptive amongst Indian couple.

Task of Indian Health care Providers (HCP):
     We, the health Care Providers (HCP), have to spread the message of usefulness of timely commencement of postpartum contraception. Admittedly, this is a huge task because In India there is 168 million eligible couple (as on 31.3.99) and on an average 2.5 million couple enter into reproductive group each year. There is always a burden of 27 million pregnant mothers with 25 million annual births. So if one intends to minimize wanted births and further population rise the same, then has to counsel all would be Indian mothers about importance of timely initiation of postpartum contraception. Admittedly, this message has to be communicated to all 25 million of women annually who are going to be mothers at or near term. For first time pregnancy of women such counseling session will probably require fifteen minutes or more depending upon the intelligence of the woman (men seldom join in counseling session at hospital). Fortunately, for multi gravid a short reminder will hopefully suffice. This will snatch much of the time of HCP and Counseling such huge number of women is not an easy task indeed. This may be the reason why Govt. of India has very recently appointed 4,00,000 female Accredited Social Health Activists (ASHA) who will act as interface between the community and the public health system for examples ANM and Doctors of community Health Centres (Source: National Rural Health Mission for 2005-12).

Miseries of unwanted child birth & abortion:
     It may be mentioned that there is approximately 1,00,000 maternal deaths in India and 22.8% mothers do not receive any antenatal care. Trained Birth Attendant (TBA) is not available during child birth in 53.4% cases and anaemia in pregnancy is ???? common (56%). Thus one can easily imagine the magnitude of the task placed before HCP of India.
     Keeping all these sufferings of Indian Women in mind let us now critically analyze how best we can help Indian mothers in postpartum period, so that they do not fall prey to accidental pregnancy in postpartum period.

The national impact of unwanted birth as evident in HFHS-3 survey (2005-06):
     The proportion of births that were not wanted at all increases sharply by birth order of children, from just I percent for first order births to 29 percent for births of order four and above. The impact of unwanted fertility can be measured by comparing the total wanted fertility rate with the total fertility rate (TFR). The total wanted fertility rate represents the level of fertility that theoretically would result if all unwanted births were prevented. The total wanted fertility rate of 1.9 is lower by 0.8 children (i.e. by 30 percent) than the total fertility rate of 2.7. This means that if unwanted births could be eliminated, the TFR would drop to below the replacement level of fertility (1.9 children per woman). The difference between the total fertility rate and the total wanted fertility rate is larger for rural women (0.9 children) than for urban women (0.5 children). Reduction of unwanted fertility amongst rural women particularly those with no education was one of the key message of NFHS-3. Because rural women and women with no education form a large proportion of the population, the TFR would drop substantially if their unwanted fertility could be eliminated.

Concluding Remarks :
     The answer to the question as to when one should start contraception after childbirth is not known her to scientists though. It is a pertinent and perplexing question to all couple. Do all women need to initiate contraceptive in postpartum period after a fixed time frame? Unfortunately, the answer is in the negative Even in twenty first. Many Indian couple are bewildved about the time of initiation of contraceptives in postpartum period. Some start too early such as couples of well to do families say few wells after childbirth. Again there are millions of women who practice contraception quite late say after couple of months after childbirth. Indian mothers do seldom have appropriate scientific knowledge on reproductive health. Another issue also remains to be explained to couple i.e. about which contraceptive will be safe during postpartum period because most mothers are worried about contraceptive induced risk of infant rather than her won risk of untimed pregnancy. Let us now place the facts before you.
 Regales of resumption of menstruation and ovulation create a problem for the care givers to advice about the initiation of contraceptives in postpartum period. Some couple and HCP are too cautions and therefore prescribe contraceptives too early white others advise to start contraceptive at a later date. Then hat is the golden rule which should be adopted by postpartum women?
     If one does not like to take any chance of unwanted pregnancy i.e. desires cent percent protection from pregnancy then fully breastfeeding women will have to use contraceptive as soon as menstruation resumes or on the very first day of seventh month of postpartum period whichever appear earlier. But for those who partially breastfeed they should not wait for resumption of menstruation. Instead, they should use contraceptive after two months of childbirth the latest.
     We know that the inhibition of egg release process primarily depend on duration of suckling. The longer the lactation is continued, the more likely that the ovulation process (i.e. monthly release of eggs) will remain suspended. This made of ovulatory suppression effect disappears quickly once complementary feeding (extra drink or food) is introduced i.e. partial breastfeeding.
     Unfortunately in India the median length of ‘exclusive breastfeeding’ is only two months and the median length of ‘predominant breastfeeding’ i.e. breastfeeding plus supplementing plain water and/or non-milk liquids is five months. As explained earlier, supplementation and bottle feeding has a direct effect on the mother’s exposure to the risk of pregnancy because the period of amenorrhoea may be shortened when breastfeeding is reduced or completely replaced by bottle feeding. Early supplementation is thus a gross negligence on the part of mother, family members and possibly caregivers counselors too. Because incomplete factual counseling during prenatal visits may be the main cause of such irrational and unscientific breastfeeding practice in India.
     Regarding choice of contraceptives one can choose barrier methods like made condom, pop pill, three monthly progesterone injections or IUD after six months after the birth of baby if baby is still breastfeeding. In case of Nonlactating mother in addition to those methods for mother can opt. for combined oral contraceptives or sub dermal implants (implanon Emergency contraceptives may be used in special situations).

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