Resveratrol in Endometriosis and as an alternative agent to suppress endometriotic lesion :--The solo reason
is that, wine contains small amounts
of resveratrol, <1-2 mg/8 ounces of red wine and that molecules
prevents cancer and ameliorates endometriosis progression.. Red wine has more
resveratrol than white wine because red wines are fermented with the grape
skins longer than white wines. Hence, many of the antioxidants including
resveratrol that are naturally present in the grape skins are extracted into
the wine.
How effective is Reversatolol
on suppressive effects on of endometriosis
lesion growth by Reversatolol can be concurrently
prescribed with Drospirenone containg OCP. While using a continuous regimen of a combined pill
containing drospirenone and ethinyl estradiol, the concomitant use of
resveratrol at a daily dose of 30 mg resulted in a significant reduction in the
number of patients reporting the occurrence of pain. Growing evidence
indicates that this compound possesses A) antineoplastic,B) anti-inflammatory
and C) antioxidant
properties. Resveratrol is a potent D) inhibitor of vascularization in
endometriotic lesions
.E) Resveratrol is a pleiotropic agent, which
dose- dependently suppresses the development of new blood vessels. All these
properties collectively, cause the suppression of endometriosis lesion growth.
Effect on cancer Besides
having documente effect o endometriosis , Resveratrol has also been shown to
exhibit profound in vitro and in vivo G) Effect on cancer :-Growth
inhibiting and apoptosis - inducing activities in several biological systems,
cancer cell lines and animal models of carcinogenesis. These properties have
been linked to inhibition of proliferation in association with cell cycle
arrest and, in some systems, with increased apoptotic cell death. Mechanisms of
action of resveratrol further include multiple cellular targets affecting
various signal transduction pathways, including AKT, RPS6KB2 (p70S6K),
mitogen-activated protein kinase 1/3 (MAPK1/3; ERK1/2), STAB, MAPK14 (P38),
protein kinase C and peroxisome proliferator-activated receptors (PPARs)-gamma.
Importantly, several of these pathways arc relevant to the pathophysiology of
endometriosis
Wherefrom we can
get Resveratrol:-Resveratrol is also present in the seeds and pomace of grapes . R
..
What are new agents for endometriosis?? Anti angiogenic agents of different substance groups are currently
discussed as promising candidates for future endometriosis therapy. Besides specific
1) growth factor antagonists, 2) endogenous angiogenesis inhibitors, 3) statins,
4) cyclooxygenase-2 inhibitors and 5) other immunomodulators, exert antiangiogenic effects ,In this category 6) also include several phytochemical compounds.
The latter ones have been successfully used in traditional medicine without
inducing severe side effects what extent there is association between endometriosis and
infertility is still undefined .The medical therapy for endometriosis is
symptomatic rather than curative and most patients experience pain relapse at
suspension of treatment because restoration of ovulation and of physiological levels of estrogen
restore the metabolic activity of both eutopic and ectopic endometrium.
Unfortunately, these
approaches often have only modest success and are associated with significant
risk of complications and side effects; consequently, the search continues for
new, safe and effective long-term treatments. This leads to development of
newer modalities in the management of disease.
The often subtle and varied
appearances of endometriosis can make recognition and surgical staging
difficult, thereby casting doubt on the utility of the classification systems
that have been developed. Nevertheless, the findings of well-designed clinical
trials and recent studies that elucidated the pathogenesis of endometriosis
have enabled a more rational approach to the medical and surgical management of
endometriosis.
. Thus, in view of their favorable
risk profile, they may be also highly preferable for the safe treatment of
endometriosis patients .
However, the association
between endometriosis and infertility is still undefined, and there are scanty
data to support the many hormonal and surgical therapies that have been
proposed. All these controversies and uncertainties have led to use of certain
unconventional or less documented therapies, which may be helpful in managing
the disease or preventing the complications..
It is widely accepted that peritoneal endometriotic
lesions develop from endometrial tissue fragments, which are retrogradly shed
through the fallopian tubes during menstruation. During the past few years,
numerous studies could demonstrate that the establishment and survival of these
lesions is crucially dependent on the formation of blood vessels, which
guarantee their oxygen supply. Accordingly, -
.
Resveratrol is one such natural phytoalexin, which represents
one of the most frequently analysed phytochemical compounds in life sciences
during the last decades. phytochemical treatment of endometriosis. Because
resveratrol exerts a broad spectrum of beneficial effects under various
pathological conditions, it has been suggested as a promising therapeutic agent
for the treatment of cancer as well as several inflammatory, metabolic and
cardiovascular diseases.
Resveratrol
is a polyphenol synthesized by plants following ultraviolet radiation and
fungal infections. Resveratrol (3,5,4’-trihydroxy-trans-stilbene) is found in
red grape skin, Japanese knotweed (Polygonum cuspidatum), peanuts, blueberries
and some other berries. A large amount of resveratrol is produced in the skin
of grapes to protect the plant against fungal diseases and sun damage;
therefore, wine has higher
levels of resveratrol compared to other natural food. Overall, red wine
contains small amounts of resveratrol, <1-2 mg/8 ounces of red wine.
However, red wine has more resveratrol than white wine because red wines are
fermented with the grape skins longer than white wines. Hence, many of the
antioxidants including resveratrol that are naturally present in the grape
skins are extracted into the wine. Resveratrol is also present in the seeds and
pomace of grapes
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