Currently, risk assessment has transitioned into the first trimester,. Various paradigms for
first-trimester or integrated first- and
second-trimester screening have resulted in the detection of 85% to 98% of
fetuses with trisomy 21, with a false positive rate of 5%. As of now, it is recommended that all pregnant women be offered prenatal screening for aneuploidy Different
sonographic metrics in conjunction with serum analytes(So called Double
markers) are used to confer a patient-
specific risk of aneuploidy.
What Is then,
the Importance of Second Trimester “Soft
Markers” ? Ans: Yes, second trimester scan has an important value but couple
would like to know status of foetus as early as possible i,e at end of first
trimester. Currently, risk assessment has transitioned into the first trimester, in which as mentioned
earlier that the sonographic metrics in
conjunction with serum analytes are used to confer a patient- specific risk of
aneuploidy. The nasal bone was recorded as “not requested” or if requested
as “present,” “absent,” or “unable to obtain.” In the case of an absent nasal
bone, 2 consecutive evaluations, typically 1 week apart, were required to
definitively report the nasal bone as absent.
The question
that remains is whether there is any importance to a soft marker for aneuploidy
in the second trimester fetus with normal anatomic survey results once a risk
of Down syndrome has been established in the first trimester.
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