Creatine sachet in tr of FGR!!!!!! Stretch
your imagination: Post delivery well being of neonate/infant where there is an
anticipation that fetus is so growth retarded that it has to be taken out by
30-234 weeks?? In such settings in addition of L arginine, Multivitamin, Sildenafil
vaginal, will creatine sachet administerd orally reduce subsequent MR (mental retardation)
, autism, or behavioral/Learning disorders after a FGR is born preterm . I have
a feeling that creatine sachets (many brands are available in Indian market designed
for nerve growth) will act better than Mag So4.
Why creatine sachets in FGR?? High creatine intake does not greatly increase plasma creatinine concentration, and increases only the excretion of creatine, not
of creatinine (Poortmans and Francaux, 1999).
How
does oral suppl f creatine helps in FGR foetus?? Ans: Creatine and creatine phosphate play important
roles in regulating cellular adenosine triphosphate reservation.
The function is impaired in cerebral creatine deficiency syndromes. This group
of disorders includes a defect of the X-linked creatine transporter (XCrT) as
well as deficiencies of two enzymes involved in de novo creatine
synthesis, arginine-glycine amidinotransferase (AGAT)
and guanidinoacetate methyltransferase (GAMT).
Major clinical
features include seizures, intellectual disability, autism, and speech delay. While there is a
significant amount of phenotypic overlap, these disorders are distinct in their
presentation and pathogenesis. Laboratory diagnosis of these disorders
relies on the determination of creatine and guanidinoacetate in both plasma and
urine. Whereas determination of plasma creatine and guanidinoacetate levels are
used for detecting AGAT
and GAMT deficiencies, measurement of urinary creatine to creatinine ratio is a sensitive screening for XCrT
deficiency. Management of cerebral creatine deficiency syndromes generally
includes creatine supplementation and attempts to reduce offending
intermediates such as guanidinoacetate. Do members’ believe that VEGF gene
therapy aiming to improve poor placentation and/or
poor uterine blood
flow will minimize FGR?? . How
many member have a feeling that Melatonin, creatine
and N-acetyl cysteine have
potential as novel neuroprotective and
cardio protective agents in established FGR.?
More about usefulness of creatine supplementation in FGR : Creatine
is considered a safe nutritional supplement for adult humans and has been shown
not only to increase muscle mass and performance, prevent disease-induced
muscle atrophy and improve rehabilitation, but also to strengthen cellular
energetics in general.. By maintaining tissue energy levels and preventing oxidative stress,
elevating tissue creatine levels by dietary supplementation is able to prevent
tissue injury induced by hypoxia( as happens in PIH induced FGR) and circulatory collapse.
In addition to yielding ATP, the dephosphorylation of creatine utilizes free
protons and ADP, thereby reducing the fall of intracellular pH and aiding in
the stabilization of the
mitochondrial membrane potential.
Creatine may also have important modulatory effects on the
glutamate and GABA-A receptor systems that raise the threshold for the onset of
excitotoxicity in the brain. The importance of creatine may extend beyond
protecting the brain to preventing damage to other organs.
More about usefulness of creatine supplementation in FGR in
pregnancy:: In pregnancy hypoxia, inflammation, and oxidative stress are
reasonably common events that lead to compromise of not only the brain, but
other important organ systems, rendering them particularly vulnerable to
hypoxic-ischemic damage that can occur at birth, particularly preterm birth.
The use of creatine in human pregnancy and neonatal practice should therefore
be evaluated as a possible prophylactic therapy in its own right, or as an
adjunct to conventional treatments such as magnesium sulphate when preterm
labour is likely, or in HIE when hypothermia is used. The regulation of creatine synthesis in brain,
pancreas, testis,
and other tissues is largely autonomous and independent of bulk production
rates in kidneys and liver.Inhibition of expression and activity of glycine amidinotransferase
(EC2.1.4.1) by its down-stream product creatine appear to be the major
regulatory events that control endogenous creatine synthesis .Thyroxin and
growth hormone stimulate this rate-limiting step, low and vitamin E
deficiency slow it down. Then followings are Indian Brands of
creatine Sachet :-
|
MuscleBlaze CreaPRO Creatine with
Creapure, Unflavoured 0.55 lb |
Rs. 524 |
|
ON (Optimum Nutrition) Micronized Creatine Powder,
Unflavoured 0.66 lb |
Rs. 1040 |
|
MuscleTech Platinum 100% Creatine,
Unflavoured 0.88 lb |
Rs. 1398 |
No comments:
Post a Comment