Resistin: It's role in causation in PCO

Serum resistin levels were significantly elevated in PCOS patients compared to controls irrespective of BMI which is a consistent findings. Therefore there is a significant inverse correlations between serum resistin level and BMI as well as WHR in both the PCOS and control group suggesting that obesity parameters negatively influence serum resistin levels 

We did not establish a link between resistin levels and HOMA IR values or between resistin and the levels of androgen hormones in women with PCOS Surprisingly FT remained a significant independent predictor of serum resisrin levels when we controlled for CPOS BMI , WHR HOMA IR , LH and TT in a stepwise regression model

In stepwise multiple regression analysis when a diagnosis of PCOS BMI , WHR , HOMA IR , LH , TT and FT were included as independent explanatory variables of the concentration of serum resistin a PCOS diagnosis was the strongest predictor among them .

Ghrelin

Many studies have revealed that there is lower serum ghrelin levels in PCOS patients have been observed than in healthy women irrespective of BMI which is consistent with data published by many authors. Thus , therefore there is a significant negative association between serum ghrelin levels and HOMA IR in the PCOS group but this association was lost after adjustment for BMI and WHR. The link between the concentrations of serum ghrelin and TT or FT in women with PCOS is still debatable..

The stepwise multiple regression model demonstrated that the variability of serum ghrelin could be explained by a PCOS diagnosis BMI and HOMA IR as confounding factors A PCOS diagnosis made the largest unique contribution to predicting serum ghrelin levels.

Leptin Adiponectin resistin and ghrelin Model of PCOS Take home message :-There is altered secretion of leptin Adiponectin resistin and ghrelin in PCOS patients compared to healthy subjects irrespective of obesity parameters. Till date it is not clear whether IR and increased production of androgens unique to the diagnosis of PCOS affect serum levels of adipokines and ghrelin in women with PCOS or the primarily defect lie with Leptin Adiponectin resistin and ghrelin

In all stepwise multiple regression models a PCOS diagnosis made the largest unique contribution to predicting serum leptin adiponectin resistin and ghrelin levels Therefore it is likely that other factors independent of obesity .