Associated diseases or syndromes with long standing PCO??

 

What are the diseases or syndromes associated with long standing PCO?? The syndrome  is also associated  with other  distressing  phenomena   such as depression , negative self esteem and metabolic   dysfunction  characterized  by insulin resistance  and compensatory  hyperinsulinaemia. PCOS  increases  the risk for type   2 diabetes   mellitus,   gestational    diabetes  and other pregnancy  related   complications.

 Women   with PCOS    also more   often have hypertension .Finally, if  left  untreated , due to unopposed  estrogen exposure   women  with PCOS   are at an increased risk to develop  endometrial   cancer. Phenotypes of PCO may change!!!! The    PCOS   phenotype might change with   increasing   age or  changes  in body mass.