A recent review by provided an overview of some of the biochemical markers that predict oocyte quality in follicular fluid. The markers were categorized into the following:
• Hormones such as growth hormone (GH), gonadotropins, and prolactin (PRL)
• Growth factors of the transforming growth factor-β (TGF-β) superfamily, for example
inhibin, activin, and anti-mullerian hormone (AMH)
• Other growth factors like insulin-like growth factors (IGF) and amphiregulin,
and interleukins (IL) such as FF IL-1β and IL-12
• Reactive oxygen species (ROS) such as nitric oxide (NO) and antioxidant
factors
• Anti-apoptotic factors
• Proteins, peptides and amino acids, for example alpha fetoprotein (AFP),
oocyte maturation inhibitor (OMI) and homocysteine
• Sugars like hyaluronan and myo-inositol
• Prostanoids such as prostaglandin F2alpha
In addition to the morphological and gene expression analysis of
oocytes, molecular predictors in follicular fluid hold great potential
in providing precise information to embryologists for the selection of
optimal quality oocytes; thereby improving embryo quality and ART outcome.
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