Saturday, 28 September 2019

Diabetes-Treatemnt by Gynaecologists!! -Why not??


All about Diabetes:-Q.4: What action should be taken to minimize macrovascular   diseases associated with diabetes people in IGT ?? .Then what to do-?? How the person concerned   can minimize vascular diseases??  Ans:-With a) control of weight with prudent diet and b) physical   exercise   approximately 50% people with IGT   revert back to normal.  Some remain   in IGT range while others slip into clear diabetic range over a course of time.

  • Q.5:- What  is the progression rate of IGT to Frank DM per year??  Ans:-On an average every year 5% of people with IGT group will proceed to Frank DM per year.  There is no urgency to put all IGT on OAD(oral antidiabetic in a hurry)   .Instead    they(IGT)  need proper diet control exercise and six monthly follow up with blood glucose estimation. Those who are unlikely to follow diet and exercise regimen can be   put on metformin or acarbose. Q, 6 What are the list of OAD agents?? However the list oral antidiabetic agents (misnomer is oral oral hypoglycemic agents are) Sulphonylureas (glipizide, glyburide, gliclazide, glimepiride)
  • Meglitinides (Repaglinide and nateglinide)
  • Biguanides (Metformin)
  • Thiazolidinediones (rosiglitazone, Pioglitazone)
  • α-Glucosidase inhibitors (acarbose, miglitol, voglibose)
  • DPP-4 inhibitors (sitagliptin, Saxagliptin, vildagliptin, linagliptin, alogliptin)
  • SGLT2 inhibitors (dapagliflozin and dapagliflozin)
  • Cycloset (Bromocriptine)
FDA approved indications for the use of oral hypoglycemic drugs are type 2 diabetes mellitus.
Non-FDA approved indications of some oral hypoglycemic drugs, such as metformin, are for the prevention of type 2 diabetes mellitus, polycystic ovary syndrome with menstrual irregularities, weight loss, gestational diabetes mellitus, and prevention of ovarian hyperstimulation syndrome.

Tips 7:- How authentic / representative is blood glucose estimation?? Does it (results) vary from one lab to another lab?? What was the recommendations and conclusion of International Committee American Diabetes Association’s annual Congress in June 2009 in this regard ??
Members will be surprised to know that :-
1)                  At present there is no single gold standard test for the diagnosis of diabetes.
2)                  The measure  to capture chronic exposure to glucose (HBA1C) is more likely to be informative  presence of diabetes than single measure of glucose!!!! But we usually avoid this tets for cost factor.

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