All about Diabetes:-Q.4: What action should be taken to minimize macrovascular diseases associated with diabetes people in
IGT ?? .Then what to do-??
How the person concerned can minimize vascular diseases?? Ans:-With a) control of weight with prudent
diet and b) physical exercise approximately 50% people with IGT revert back to normal. Some remain
in IGT range while others slip into clear diabetic range over a course
of time.
- Q.5:- What is the progression rate of IGT to Frank
DM per year?? Ans:-On an
average every year 5% of people with IGT group will proceed to Frank DM
per year. There is no urgency to
put all IGT on OAD(oral antidiabetic in a hurry) .Instead they(IGT) need proper diet control exercise and six
monthly follow up with blood glucose estimation. Those who are unlikely to
follow diet and exercise regimen can be
put on metformin or
acarbose. Q, 6 What are the list of OAD agents?? However
the list oral antidiabetic agents (misnomer is oral oral hypoglycemic
agents are) Sulphonylureas (glipizide, glyburide, gliclazide, glimepiride)
- Meglitinides (Repaglinide and nateglinide)
- Biguanides (Metformin)
- Thiazolidinediones (rosiglitazone, Pioglitazone)
- α-Glucosidase inhibitors (acarbose, miglitol,
voglibose)
- DPP-4 inhibitors (sitagliptin, Saxagliptin,
vildagliptin, linagliptin, alogliptin)
- SGLT2 inhibitors (dapagliflozin and dapagliflozin)
- Cycloset (Bromocriptine)
FDA
approved indications for the use of oral
hypoglycemic drugs are type 2 diabetes mellitus.
Non-FDA
approved indications of
some oral hypoglycemic drugs, such as metformin, are for the prevention of
type 2 diabetes mellitus, polycystic ovary syndrome with menstrual
irregularities, weight loss, gestational diabetes mellitus, and prevention of
ovarian hyperstimulation syndrome.
Tips
7:- How
authentic / representative is blood glucose estimation?? Does it (results) vary
from one lab to another lab?? What was the recommendations and conclusion of
International Committee American Diabetes Association’s annual Congress in June
2009 in this regard ??
Members will be surprised to know that :-
1)
At present there is no single gold
standard test for the diagnosis of diabetes.
2)
The
measure to capture chronic exposure to glucose (HBA1C) is more
likely to be informative presence of
diabetes than single measure of glucose!!!! But we usually avoid this tets for
cost factor.
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