Saturday, 28 September 2019

G D M & Frank DM

Tips on Fructosamine Test : listen what Dr S K Pal has to say? Ans: Fructosamine Test is not that helpful in day to day  clinical practice. I, Dr Pal don’t recommend to do such tests (Fructosamine    )which are insignificant.
Why dislike Fructosamine tests ?? Because though like HbA1c Fructosamine  is a blood  test in which glycated plasma proteins are measured and expressed as percentage of total plasma proteins but it(Fructosamine  ) gives  information  on average metabolic control  over the previous  two weeks it is not yet regularly  done in our country. It  is more  useful than HbA1c  to access metabolic  control during  pregnancy.
Treat DM women by yourself. Listen what Dr S K Pal has to say on the Advantages of HBA1c  over Fructosamine??   Point 1;-HBA1c derived average  glucose  a new patient  friendly concept  of expressing metabolic  control
Point Glycosylated haemolglobin HbA1c   a gold standard in assessing metabolic control   is expressed in % value. The bad aspect of HBA1c??  a) Even though it is an indicator of average  blood glucose control since  the unit  of expression is to in mg%   and since the values are at variance with blood glucose    values the expression is not patient  friendly . Better at least for research work one can perform  continuous interstitial fluid  glucose  monitoring for 48  hours( like Holters)  every few months particularly who are on insulin pump. monitoring  seven times a day three  times a week for 4 months for 4  months In addition they were subjected to HbA1c   estimation 3 times at a central laboratory in Europe Participants also  underwent self capillary glucose. From this data average  glucose value was calculated and it’s  correlation with HbA1c  was worked out and a mathematical formula to convert HbA1c  in to average glucose  value  was developed Interstitial fluid values  were scaled up by 5% to derive capillary glucose values 


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: Listen what Dr S K Pal has to say on  rational & timely use   of Glucometer in family practice provided the paper strips are not out of stalk & her/his eye sight is normal!! Presence of an maid servant who can read English will beef immense help. The instrument warrants 2 yarely servicing.
In a day to day practice of a family physician or general duty medical officer he commonly  has to deal  with routine management   including dosage      adjustments and also  handle  emergencies in a diabetic patient . thus  a properly  functioning  glucometer  with all the accessories is a must for him both   in th clinic  and in emergency bag. Glucometer  is an essential to a clinician as a stethoscope blood pressure  apparatus  and a torch.
Applications  of glucometer in family  physician’s clinic
1)                     When  a patient  walks in with symptoms  suggestive of  diabetes. Even  though one should not  solely rely on glucometer  readings  when hyperglycemia is detected for value  will definitely  help in planning   of  further line of action including  the investigations
2)                     When a known diabetic visits the clinic for routine check  upon the eve of his departure  from the city  and thus does not have  a time for formal laboratory tests in near  future.
3)                     When  a known diabetic  attends the clinic with  symptoms which  may or may not be related to diabetes  and does  not have  a recent   laboratory  blood glucose  report.
4)                     On emergency visit. On the spot blood glucose  estimation  is a must  at  every emergency
Symptoms such as hunger palpitations sudden sweating giddiness etc could be due to hypoglycemia  Random blood glucose  on the spots  helps  to detect   or rule out hypoglycemia. In case   of hypoglycemia one should immediately correct  the low blood glucose level by serving a carbohydrate  snack  like biscuits or refined sugar  containing  liquids and subsequently   reduce dosage of his anti diabetic medications if required . In case in te patient is semi conscious or unconscious 50 ml of 25% glucose should  be injected intravenously . Hypoglycemia  in patients  on alpha  glucosidase  inhibitors should be treated by administering oral or intravenous  glucose as it does not respond to carbohydrate     snacks  or table sugar On the spot blood glucose   estimation with glucometer also helps to rule out hypoglycemia and think of alternative condition Sudden  sweating could be a symptom of acute myocardial infarction since   hypoglycemia is more common there  is a tendency in patients  to assume  that they are having hypoglycemia   and to consume two teaspoons of sugar every  10 minutes. In case of  heart attack it leads to late   diagnosis and loss of vital  time before the patient is admitted in intensive care  unit. Thus  timely on the spot blood  glucose estimation  can save  precious  time and   life as well as  lots of money  by avoiding delay  in hospitalization  in case  of serious  condition such as  acute myocardial infarction or other cardiac  emergencies or by avoiding  unnecessary hospitalization in case of simple  hypoglycemic episode  Prompt  use  of glucometer  and swift appropriate  action in only one episode  will more  than compensate for  the entire investment   cost  of glucometer.

Equipment  required for home blood glucose monitoring 
1)         Reliable  glucometer
2)         Chemically treated   strips  compatible  with the meter
3)         Lancets or fine needles to  prick the finger for a drop of blood
4)         Cotton  swabs
5)         Methyl alcohol or medicated spirit.
Glucometer : It is small electronic  instrument which  analyzes the concentration of glucose in a drop  of blood  transferred on chemically treated plastic stick  from patient’s  finger. The strip is inserted  in a slot on the meter,. Glucometer  runs on batteries. Several  brands are available in our country.                 
The cost  of the meter  varies from Rs 850/ to Rs 3000/ For those with high consumption of strips  many companies  offer free glucometers. The high end meters  have additional  features such as  varying memory capacity to store  previous readings along  with   date   and time automatic calculation  and display of mean  blood glucose  value  of last 15 days warning  beep  and message  if the values are out  of range  on either  side facility to download  the readings to computer  coding free operations etc.
Once a drop of blood from finger after  a prick with the lancet or needle is deposited on the designated area on the plastic strip which  is  inserted in the slot on the meter  the blood glucose   value is digitally displayed on the meter  screen in  five to fifteen seconds. One plastic stick is required for each test . The cost of strip works  out to be  in the range  of Rs 14  -25/   depending upon the meter and the number of strips  purchased at a time. These strips are  available  in vials usually each vial contains 25  strips. They  have unopened expiry period of about 16 months and six  months after the seal is opened. The disposable lancets and needles cost approximately Res 1-4 the pain following finger prick particularly when spring loaded lancet device is used is minimal and easily bearable. All  meters come  with a spring loaded lancet  device at no extra cost

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