Clomiphen citrate

Why En is better?

En & Zuclomiphene. En is more potent as OI. Half life is short, But Zu last long in the body as many as 1 month after stimulation. In obese women higher dose –no benefit.

 Q.4. What is the prevalence of CC resistance case & how do we treat that?    About 20-25 % cases do not respond to CC. The options are further investigations & treat with followings:-

.

 Q.5. Is there any Carry Over Effect?

 Although there is no evidence of a “carryover effect” of CLOMID, spontaneous ovulatory menses have been noted in some patients after CLOMID therapy.

1

Q.5. what is the pregnancy rates?

CLINICAL STUDIES

During clinical investigations, 7578 patients received CLOMID, some of whom had

impediments to ovulation other than ovulatory dysfunction (see INDICATIONS AND USAGE).

In those clinical trials, successful therapy characterized by pregnancy occurred in approximately

30% of these patients.

There were a total of 2635 pregnancies reported during the clinical trial period. Of those

pregnancies, information on outcome was only available for 2369 of the cases. Table 1

summarizes the outcome of these cases.

Of the reported pregnancies, the incidence of multiple pregnancies was 7.98%: 6.9% twin, 0.5%

triplet, 0.3% quadruplet, and 0.1% quintuplet. Of the 165 twin pregnancies for which sufficient

information was available; the ratio of monozygotic to dizygotic twins was about 1:5