Y chromosome dekltion in males with azoospermia

Y-chromosome microdeletions on male

Major focus of our research on male infertility is on elucidating the genetic and chromosomal abnormalities in non obstructive azoospermia and severe   oligoasthenozoospermia. The possibility of microdeletions of Y-chromosome and

A chromosomal aberration in these cases is being investigated in detail. Studies so far have revealed a frequency of 5.3% of Y chromosome microdeletions and 7%abnormal karyotype (Klinefelter’s mosaic) in these cases. The most frequent

deletions were seen in AZF b and AZFc regions of the Y chromosome. Screening for these loci therefore can provide valuable adjuncts to assisted reproductive techniques like ICSI to prevent transmission of these genetic abnormalities to the

progeny. The functional role of the spermatogenic genes and their proteins are being analysed with reference to aberrant spermatogenesis.