Management
If a woman has primary infection with CMV, there is a 30% chance her child will be infected and thus, approximately a 6 to 7% chance her child will have some damage due to this infection. In about half of the cases the damage will be evident at birth. Therapeutic abortion can be considered. There can be a role for amniocentesis and amniotic fluid polymerase chain reaction (PCR) for CMV to assessment in utero infecn. . A negative test should rule out fetal infection; however, a positive test would not necessarily indicate that the fetus is damaged.
Recent studies suggest that there may be role for anti-CMV-specific hyperimmune globulin as prophylaxis to reduce the risk of fetal infection after maternal infection and as treatment to prevent fetal sequelae after in utero infection. However, prospective randomized studies are needed in larger groups of infected women to examine the efficacy and safety of this therapy, before this strategy can be recommended. Women who have antibody (IgG) to CMV before being pregnant can be assured that it is very unlikely that subsequent children will have sequelae due to congenital CMV infectio
If a woman has primary infection with CMV, there is a 30% chance her child will be infected and thus, approximately a 6 to 7% chance her child will have some damage due to this infection. In about half of the cases the damage will be evident at birth. Therapeutic abortion can be considered. There can be a role for amniocentesis and amniotic fluid polymerase chain reaction (PCR) for CMV to assessment in utero infecn. . A negative test should rule out fetal infection; however, a positive test would not necessarily indicate that the fetus is damaged.
Recent studies suggest that there may be role for anti-CMV-specific hyperimmune globulin as prophylaxis to reduce the risk of fetal infection after maternal infection and as treatment to prevent fetal sequelae after in utero infection. However, prospective randomized studies are needed in larger groups of infected women to examine the efficacy and safety of this therapy, before this strategy can be recommended. Women who have antibody (IgG) to CMV before being pregnant can be assured that it is very unlikely that subsequent children will have sequelae due to congenital CMV infectio
No comments:
Post a Comment