What are the available
options before us if we decide for & woman concerned agrees to accept for hormonal
tr for
certain specified period?? The
followings are the drug options for women with intact uterus? 1) Cyclical
basis, not continuous:-Conj. Oestrogen alone for 3 weeks—gap for 7 days
--- cyclical. 2) Continuous combined :-Conj. Oestrogen & MPA (0.625 &
MPA 2.5 mg as daily basis 3) Sequential
but combined i.e. same
formulation for 3 weeks and 1 week off. 4) Same formulations: Monday to Friday. 3) Low dose daily Oestrogen only i..e. Premarin 0.3mg. 4) Continuous
combined: oestrogen and cyclical
progesterone 5) Tibolone 6) Progesterone alone (Norethindrone
alone Noreta HRT 1 mg- but but but what
about ? br Ca if she don’t report for
regular check up à say lost to follow up ??
The other
options:-. What are hormonal options
available as HRT for a woman who had hysterectomy & BSO? 1) Conj. Oestrogen alone FOR 3 WEEKS-
cyclical 2) Continuous combined
Conj. Oestrogen & MPA 3) Tibolone.
Q. 4:-Any scope of Inj.
Androgens./ Tab form in menopause??
Ans: Not very much. ---> Only in selected cases where there is poor sex
drive !! May be!! . Drug are 1) Restore Tab?
ESTRATESTtAB( E 2 & Methyl Testosterone tab/ Mesterolone/ provironum )
Q. 5:-Is it true that Prog
Challenge test should be always employed
before initiation of HRT. If she bleeds HRT should be avoided. What about
Tibolone? Should we do such PCT ??
. Q 6:-. Is there any
chance of systemic absorption if someone uses EVALON CREAM for years together? Q. 7: Someone
is having bleeding after Tibolone Ry.--What should be done? What are the possible causes in such
situation? Hysteroscopy after USG. Or wait & watch.
Q. 8> Any member
prescribes micro gram alpha Calcidol? Is there any clinical
situation where one has to estimate ration of E2/E1 (menopause = 0.23)
Q, 9:--What about
Transdermal oestrogen suppl in Indian context?
PATCH / CREAMS? Which one members
prefer in Indian context (Non oral HRT maintain E2/E1 ratio in a better
way-acceptable to us- i.e. above 1.
Why it has not become that popular?
I believe in cases where high dose of oestrogens are not wanted the one
can opt for skin patches/implants (slow release) e.g. CHD, HTN, DM,
Estraderm /oestrogel/Sandrine gel/
IMPLANTS?
VAGIFEN(sustained Release E2 Novo
Nordsk co.)
Q, 8:- Is
Indian Menopausal Society is propagating this message to gynaecologists?
It is often
quoted that HRT should be usually administered for about 7 yrs after attaining natural menopause unless
there is some medical sytemic compl./
local pathology .Is that true? Or some members like to stop oat 52 yrs of age? In
cases of family H/O Br Ca-avoid oestrogens or Progesterone as HRT? What about following agents ?
ESPAUZ (G. R). NORETA HRT 1mg Norethindrone,
Styptin 5mg. Premelle . Prempro,
Progynova (E1?-oestrone? Oetradiol Valerate) , Evalon Cream
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