Sunday, 17 November 2019

Sperm DNA damage : When this possibility should be considered and sperm function ordered??

Sperm DNA damage : When this possibility should be considered and sperm function ordered??Why afraid of insisting on sperm function tests in unexplained subfertility? What prevents most of us -Paucity of quality centers competent to carry out sperm function tests? Gd centres? To much expenses? The couple imagines tat the treating doctor is insisting on ART
? Do you believe me when I say "Basic semen analysis gives information about the messenger whereas sperm DNA integrity tests reveal information about the message"?
Sperm DNA damage is not written in his face!!!  Why sperm function tests are essential if no definite cause is established by 2 yrs time(trying time > 2 yrs) ??  Ans: DNA damage is not written in his face  DNA damage can affect    the motility of sperm and DNA damage have a   2) negative influence of blastocyst development .3) more oxidative   stressà more is the  DNA   damage       4) MAGI-à leukocytospermia due to infn of male accessory glands   may not only cause impaired sperm motility but also  DNA   damage. Further, leukocytospermia is one of the main   causes of oxidative stress.. 4)   How important is male accessory glands?  The improper function of such glands (S vesicles, prostrate)      not only yield to more DFI(DNA Fragmentation Index)   but also    the proper orderly functionality    of accessory  glands    is  essential    for advanced sperm    function  . 5) There is correlation between seminal adenosine deaminase and increased   sperm DNA damage thus making it a good indicator of male genital tract    inflammation(MAGI = male genital Tract infection)  and low quality. semen.6) Seldom we look at the report page about fructose and citric acid us rarely estimated at the lost cost of 500-1000 /-of routine semen analysis,. But fact is even evaluation of fructose  and citric   acid can   help in understanding the sperm function.



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