How important is maternal
health at pregnancy period? Many researchers have suggested that a fair number of male subfertility are due to
ever increasing environmental pollution
and poor substandard neutrino of Indian
mothers ROS is another factor mediated by Vehicular pollution, Alcohol & tobacco.--à all causing to disruption of embryonal programming and
gonadal development during fetal life
For instance , testicular dysgenesis syndrome: an increasingly common developmental
disorder with environmental aspects:
Opinion have recently focused on various aspects of adverse trends in
male reproductive health, low and probably declining semen quality; high and
possibly increasing frequencies of undescended testis and hypospadias; and an
apparently growing demand for assisted reproduction.
. Experimental and
epidemiological studies suggest that TDS is a result of disruption of
embryonal programming and gonadal development during fetal life.
Therefore, we recommend that future epidemiological studies on trends in male
reproductive health should not focus on one symptom only, but be more
comprehensive and take all aspects of TDS into account. Otherwise, important
biological information may be lost.
ss men?? Growing evidence from clinical
observations of individual patients and from larger epidemiological studies
indicates a synchronized increase in the incidence of male reproductive
problems, such as testicular cancer, genital abnormalities, reduced semen
quality and subfertility. Temporal and geographical associations, as well as
frequent combination of more than one problem in one individual, strongly
suggests the existence of a pathogenetic link. The association of male
reproductive problems is probably not coincidental but reflects the existence
of a common underlying cause resulting in a maldeveloped testis. We named the
resulting phenotype the testicular dysgenesis syndrome (TDS). Experimental
biological investigations and epidemiological studies leave little doubt that
the TDS can be a result of disruption of embryonal programming and gonadal
development during fetal life. As the rise in the incidence of the various
symptoms of TDS occurred rapidly over few generations, the aetiological impact
of adverse environmental factors such as hormone disrupters, probably acting
upon a susceptible genetic background, must be considered(Courtesy:. Clinical Endocrinology
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