What drugs can increase PRL??

?? Pharmacological agents causing Hyperprolactinaemia:-Resperidone, olanzapin, phenothiazine, Clomipramine, pimozide, haloperidol, & domperidone. Four days after Ry stoppage of this drugs the PRL will hopefully come to normal. Additionally, MAO inhibitors (pargyline, clorgyline,   opiate antidepressants codeine, Desipramine, Amitryptiline, Clomipramine all can raise of PRL...  If menst function remains normal then :-A) Hyperprolactinemia-induced estrogen deficiency is a possibility, but if   cycles remains undisturbed the one can ignore the serum PRL level temporarily. But it is questioned that menst function reamaing normal pattern can high PRLàlow serumE2 itself cause Osteoporosis ?? Therefore not only subfertility, LPD, abnormal folliculogenesis, we have to consider possibility of accelerated bone loss due to hyperprolacunaemia rather than prolactin itself, is the major factor in the development of osteopenia . Therefore, estrogen replacement with typical hormone replacement regimens or hormonal contraceptives is indicated for patients with amenorrhea or irregular menses.

 Patients with drug-induced hyperprolactinemia can be managed expectantly with attention to the risks of osteoporosis. In the absence of symptoms of pituitary enlargement, imaging may be repeated in 12 months, and if prolactin levels remain stable, less frequently thereafter, to assess further growth of the microadenoma.