Self collected samples is portable and does not require running water or electricity gives rapid results in 2.5 hours thus allowing screening and follow up treatment in a single visit.

Self collected samples is portable and does not require running water or electricity gives rapid results in 2.5 hours thus allowing screening and follow up treatment in a single visit. This  new test has been developed for screening women in developing regions for cervical intraepithelial neoplasia by detecting 14 high risk hpv types. This test is simples and can be performed even by health care workers. It works on self collected samples is portable does not require running water or electricity gives rapid results in 2.5 hours thus allowing screening and follow up treatment in a single visit. It will soon be commercially available. The evaluation of clinical accuracy of care hpv as a rapid screening test in rural china for the detection of high grade cervical neoplasia showed it to be substantially better than via with sensitivities and specificities of 90.0% and 84.2% respectively on cervical specimens collected by nurse midwife and 81.4 % respectively on self collected vaginal specimens.

Efforts are underway to improve screening coverage in populations where accessibility of screening procedures or its acceptance due to social cultural factors is limited. Several studies have evaluated the diagnostic accuracy of self collected vaginal specimens using swabs brushes etc for hpv. The studies how good acceptance among women. Hence this could be valuable screening method for women who refuse to attend clinic based screening . According to a meta analysis the sensitivity of self collected vaginal specimens for hpv was 74 5 ans specificity was 88% . Clinician obtained specimens had slightly better test characteristics as compared to self collected specimens . AUK trial found similar sensitivity between clinician and self hpv tests for women with high and low grade disease. However self hpv test missed few high grade disease as compared to the clinician sample though the difference was not significant. A RCT comparing hpv screening by self sampling with clinic based cervical cytology in Mexican women found relative sensitivity of hpv testing to be 3.4 times greater with 4.2 times more detection of invasive cancers than cytology.

The persistence of oncogenic hpv is considered to be true precursor of cervical cancer. The transcription of the viral oncogenes E6 and E7 is necessary for the malignant transformation and maintenance of th neoplastic state. Several studies indicate that the up regulated expression of hpg E6/E7 genes is necessary for the initiation and progression of cervical neoplasia. A new test indentifying E6/E7 mrna as biomarker is under development which will help in differentiating women who have hpv infection from those who have begun to develop neoplastic precancerous cells studies show this test to be highly sensitive yet significantly more specific for cervical disease compared to hpv dna assays . This test has the potential to be reliable for both primary cervical cancer screening and the triage of borderline cytological abnormalities.