Monday, 21 September 2020

Antioxidants in male subfertility what antioxidants ??

 

 

 

Role of  Antioxidants and vitamins in male subfertility:-Many doctors do prescribe 1)L- carnitine,2)  Astaxanthin,3)  Vitamin E, 4) Vitamin C,  5) Co-Q, 6) Zn, 7) Lycopene, 8) Selenium, 9) L-arginine, 10) Alpha- Calcidol, 11) Omega-3 Fatty acids, 12) DHA and 13) F. Acid 14) Glutathione  to promote fertilizing potential of ejaculated sperms.. It is understandable that    role of antioxidants in male subfertility is somewhat effective as time and again it  has been noticed that the quantum of ROS in  seminal fluid is high when seminal parameters are substandard. ?? There is no  head to head trial with IUI as initial modality for suboptimal seminal parameters vis a vis  antioxidants as first modality?? I have no idea but literature is full of positive role  of antioxidants in male subfertility. AS such , still many people use varieties of antioxidants in male partner defect in empirical basis with some improvement in selected cases but not in all.     

 

What Antioxidants to improve seminal parameters and conception rate!!! Do supplementary oral antioxidants improve fertility outcomes for subfertile men when compared with placebo, no treatment or another? Recognizing the drugs are safe in prescribed dosage but not all the mentioned agents are available in any brand prepaertions.

Cost is an issue:-Antioxidants prescribed at right dose as male partner defect to counteract ROS in semen will cost approx  >  Rs 110-150/- per day and given the earliest possible pregancy will be 80-90 days as spermatogenic cycle is somewhere 74 days. Given this equation, which one is cost effective??. If one intends to improve one or multiple parameter defect when no clinical abnormality is demonstrable then antioxidants is one modality of improving seminal parameters. What antioxidants to improve seminal parameters and conception rate!!!.

Do supplementary oral antioxidants improve take home baby rate fertility outcomes for subfertile men when compared with placebo, no treatment or another?

No comments:

Post a Comment