Monday, 28 September 2020

Pruritus in pregnancy due to Obstet cholestasis

 

1)   Daily dose of UDCA is 1500 mg in three divided doses. No under dosing please in this set up

  2) Cholestyramine 4 Gm TDS

3)  activated charcoal may be tried but of questionable efficacy .

4) Chlor pheniramine maleate ( piriton tab  ) 4 mg tab 1 TDS is safe 5) Dexamethasone 12 mg orally daily.

6)  Vitamin K orally 10 mg od . 7) Rifampicin 300 mg daily  combined with UDCA 1500 mg is a good combination.

7) epomedial-failig all one may consider epomedial -a synthetic terpenoid which  reduces E 2 induced Cholestasis including pruritus.

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