Tr of Abnormal hair growth

 

1)            Metformin Why? 

2)            Because both excess insulin and elevated levels of LH stimulate ovarian androgen synthesis à

So there is a rationality of prescribing metformin in PCOS women who exhibit hirsutism as well.

3)            What is Flutamide? Andrcur? It is as effective as spironolactone.

4)             It is a non-steroidal androgen receptor antagonist

5)            Two types of enzymes plays at hair follicle level: - Type 1 5-α reductase (observed in sebaceous gland and genital areas skin)       & Type 2-5-α reductase-primarily in hair follicle and scalp.      This enzyme is activated by Testosteoneà causes vellus hair to form terminal coarse hair. Androgen excess increases hair follicle growth, size of follicle, hair fiber diameter, This Type 2-5-α reductase is also activated by insulin and insulin like growth factor. Therefore, hair growth as observed in PCOS not only is dependent on circulating androgens n but also on Insulin and IGF-1. Therefore those women who exhibit IR may have excessive hair growth.

17/) Androgenic Alopecia (Female Hair Loss). - Also called female pattern hair loss- hereditary disorder of /disruptionà poor androgen signaling. This hair loss may also occur during menopause or a woman suffering from PCOS where androgen excess persists.

What are the different phases of hair growth? Three phases of growth- e.g.  Anagen-growth phase; Catagen- the involution phase; and Telogen-resting phase. Treatment of alopecia includes Topical application of Minoxidil (Rogaine), Oral Finasteride (Propecia). Oral Finasteride (Propecia) is usually approved for hair loss in men. In women it is a trade off use.  Spironolactone and Cyproterone may help in women suffering from alopecia, occasionally hair transplantation may be of help.